摘要
目的:对各型肾虚及非肾虚型勃起功能障碍(ED)患者血液生化指标进行测定,确定各型肾虚的血液生化特点。方法:收集2018年5~7月在男科就诊的156例ED患者的临床资料,根据中医辨证分为肾阳虚组(48例)、肾阴虚组(34例)、肾阴阳两虚组(36例)及非肾虚对照组(38例),检测血液生化指标:睾酮(T),雌二醇(E2),皮质醇(CORT),促甲状腺激素(TSH),游离型甲状腺素(FT4),游离型三碘甲状腺原氨酸(FT3),一氧化氮(NO),一氧化氮合酶(NOS),诱导型一氧化氮合酶(iNOS)。结果:4组患者平均年龄、病程、国际勃起功能问卷-5评分(IIEF-5)、勃起硬度评分(EHS)无显著差异;4组患者CORT、FT3、iNOS水平两两比较显示肾阴虚组CORT水平[(121.78±41.87)μg/L]高于对照组[(87.97±45.59)μg/L,P=0.002],肾阳虚组FT3水平[(5.11±0.54)pmol/L]低于对照组[(5.44±0.38)pmol/L,P=0.008],肾阴虚组iNOS水平[(14.42±2.49)U/ml]高于对照组[(12.71±2.58)U/ml,P=0.039]和肾阳虚组[(13.05±2.17)U/ml,P=0.049],其余各组之间各指标无显著差异。结论:ED患者不同肾虚证型之间存在血液生化指标差异,发现肾虚证型之间的生化差异,有助于探明ED患者中医肾虚证型的生物基础。
Objective:To analyze the blood biochemical characteristics of the ED patients with different types of kidney deficiency or non-kidney deficiency.Methods:We reviewed the clinical data on 156 ED patients treated in our Department of Andrology from May to July 2018 and,according to the traditional Chinese medicine(TCM)syndromes,divided them into four groups:kidney-yang deficiency(n=48),kidney-yin deficiency(n=34),kidney-yin+yang deficiency(n=36)and non-kidney deficiency control(n=38).We obtained and compared their blood biochemical indexes,including the levels of testosterone(T),estradiol(E2),cortisol(CORT),thyroid stimulating hormone(TSH),free thyroxine(FT4),free triiodothyronine(FT3),nitric oxide(NO),total nitric oxide synthase(tNOS),and inducible nitric oxide synthase(iNOS).Results:There were no statistically significant differences in the mean age,course of disease,IIEF-5 score and erection hardness score(EHS)among the four groups of patients.Pairwise comparison showed that,compared with the non-kidney deficiency controls,the patients in the kidney-yin deficiency group exhibited a dramatically higher level of CORT([87.97±45.59]vs[121.78±41.87]μg/L,P=0.002)and those in the kidney-yang deficiency group a remarkably lower level of FT3([5.44±0.38]vs[5.11±0.54]pmol/L,P=0.008).The iNOS level was significantly higher in the kidney-yin deficiency group(14.42±2.49 U/ml)than in either the control(12.71±2.58 U/ml)(P=0.039)or the kidney-yang deficiency group(13.05±2.17 U/ml)(P=0.049).Conclusion:ED patients with different types of kidney deficiency syndromes have different blood biochemical indexes,which may help clarify the biological basis of the TCM syndromes of kidney deficiency in ED patients.
作者
王瑞
张天标
吕坤龙
郑涛
殷正伟
郝亚伟
南永浩
张卫星
WANG Rui;ZHANG Tian-biao;Lü Kun-long;ZHENG Tao;YIN Zheng-wei;HAO Ya-wei;NAN Yong-hao;ZHANG Wei-xing(Department of Andrology,The First Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan 450000,China)
出处
《中华男科学杂志》
CAS
CSCD
北大核心
2020年第7期645-649,共5页
National Journal of Andrology
关键词
勃起功能障碍
肾虚
阴阳
一氧化氮合酶
erectile dysfunction
kidney deficiency
yin and yang
nitric oxide synthase
