摘要
目的探讨阴道用乳酸菌胶囊辅助硝呋太尔对老年细菌性阴道炎患者氧化应激反应及阴道灌洗液Toll样受体2(TLR2)、肿瘤坏死因子-α(TNF-α)、白细胞介素-13(IL-13)水平的影响。方法选取2018年10月至2019年12月四川省宜宾市第一人民医院收治的老年细菌性阴道炎患者100例进行前瞻性随机对照研究,以随机数字表将患者分为两组:研究组和对照组,每组各50例。对照组患者采取硝呋太尔治疗,研究组患者采取阴道用乳酸菌胶囊辅助硝呋太尔治疗,均治疗2周。对比两组患者的疗效、临床症状(黏膜充血时间、外阴阴道疼痛时间、外阴瘙痒时间、白带异常)改善时间与治疗前、治疗2周后阴道微环境变化(pH值、菌群密集度)、血清氧化应激指标[超氧化物歧化酶(SOD)、丙二醛(MDA)]、阴道灌洗液TLR2、TNF-α、IL-6水平,治疗后随访3个月、6个月比较两组患者的复发率。结果治疗2周后,研究组患者的总有效率(96.00%)明显高于对照组(82.00%),差异具有统计学意义(P<0.05);研究组患者的黏膜充血时间[(6.29±1.42)d]、外阴阴道疼痛时间[(2.96±1.09)d]、外阴瘙痒时间[(4.02±1.14)d]、白带异常时间[(5.17±1.36)d]明显短于对照组[(9.14±1.86)d、(5.73±1.47)d、(6.97±1.28)d、(7.59±1.64)d],差异具有统计学意义(P<0.001);研究组患者的pH值>4.5人数比率(38.00%)明显低于对照组(72.00%),菌群密集度为2级、3级人数比率(56.00%、28.00%)明显高于对照组(28.00%、12.00%),差异均具有统计学意义(P<0.05);研究组患者的血清SOD水平[(95.63±10.74)U/ml]明显高于对照组[(86.98±9.49)U/ml],血清MDA水平[(3.54±0.28)nmol/L]明显低于对照组[(4.61±0.37)nmol/L],差异均具有统计学意义(P<0.001);研究组患者的阴道灌洗液TLR2[(4.61±0.37)ng/L]、TNF-α[(106.68±4.35)ng/L]、IL-13[(19.54±1.81)pg/ml]水平明显低于对照组[(8.71±0.82)ng/L、(119.54±6.30)ng/L、(25.39±2.17)pg/ml],差异均具有统计学意义(P<0.001);
Objective To investigate the effect of vaginal lactic acid bacteria capsules assisting Nifuratel on oxidative stress and vaginal lavage fluid Toll-like receptor 2(TLR2),tumor necrosis factor-α(TNF-α)Effects of interleukin-13(IL-13)levels.Methods A total of 100 elderly patients with bacterial vaginitis admitted to the First People's Hospital of Yibin,Sichuan Province from October 2018 to December 2019 were selected for a prospective randomized controlled study,and they were divided into two groups using a random number table:a study group and a control group,with 50 cases in each group.The control group was treated with Nifuratel,and the study group was treated with vaginal lactobacillus capsules supplemented with Nifuratel,both were treated for 2 weeks.Comparing the efficacy and the time for improvement of clinical symptoms(time of mucosal congestion,time of vulvovaginal pain,time of vulvar itching,and abnormal leucorrhea)and the changes in vaginal microenvironment(pH value,flora density),serum oxidative stress indicators[superoxide dismutase(SOD),malondialdehyde(MDA)],TLR2,TNF-α,IL-6 levels of vaginal lavage fluid before treatment and after 2 weeks of treatment of patients in the two groups.The patients were followed up for 3 months and 6 months after treatment to compare the relapse rate of the two groups of patients.Results After 2 weeks of treatment,the total effective rate of patients in the study group(96.00%)was significantly higher than that in the control group(82.00%),the difference was statistically significant(P<0.05);the time of mucosal hyperemia[(6.29±1.42)d],vulvovaginal pain time[(2.96±1.09)d],vulvar itching time[(4.02±1.14)d]and leucorrhea abnormal time[(5.17±1.36)d]of the study group were significantly shorter than those of the control group[(9.14±1.86)d,(5.73±1.47)d,(6.97±1.28)d,(7.59±1.64)d],the difference was statistically significant(P<0.001);the ratio of the number of patients with pH value>4.5 in the study group(38.00%)was significantly lower than that in the control group(72.00
作者
谭建媛
阳莉
邓凯兮
TAN Jian-yuan;YANG Li;DENG Kai-xi(Department of Gynaecology,Yibin First People's Hospital,Yibin Sichuan 644000,China)
出处
《临床和实验医学杂志》
2020年第18期1987-1991,共5页
Journal of Clinical and Experimental Medicine
基金
四川省卫生和计划生育委员会科研课题(编号:17PJ526)。
