摘要
目的观察妇炎消胶囊联合硝呋太尔制霉菌素阴道软胶囊治疗细菌性阴道炎的临床疗效。方法选取2015年10月—2017年10月在鄂东医疗集团黄石市中心医院就诊的细菌性阴道炎患者150例为研究对象,将患者随机分为对照组和治疗组,每组各75例。对照组患者于睡前清洗外阴后将1粒硝呋太尔制霉素阴道软胶囊放置于阴道深部,24 h后再进行上述操作。治疗组患者在对照组治疗的基础上口服妇炎消胶囊,3粒/次,3次/d。两组均以7 d为1个疗程,连续用药2个疗程。观察两组患者的临床疗效,同时比较两组临床体征改善时间、阴道pH值、乳酸杆菌及病原菌检出率、随访复发率。结果治疗后,对照组和治疗组的总有效率分别为81.33%、94.67%,两组比较差异具有统计学意义(P<0.05)。治疗后,治疗组患者的白带减少时间、外阴瘙痒消失时间、外阴阴道疼痛消失时间、黏膜充血消失时间均较对照组明显缩短,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者的阴道pH值、病原菌检出率均显著降低,乳酸杆菌检出率显著提高,同组治疗前后比较差异具有统计学意义(P<0.05);治疗后,治疗组阴道pH值、分泌物检出率显著优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,治疗组患者在停药6、12个月的复发率均显著小于对照组,两组比较差异具有统计学意义(P<0.05)。结论妇炎消胶囊联合硝呋太尔制霉素阴道软胶囊治疗细菌性阴道炎疗效显著,能显著降低阴道pH值和病原菌水平,提高阴道乳酸杆菌水平,减少复发率,具有一定的临床推广应用价值。
Objective To observe the clinical efficacy of Fuyanxiao Capsules combined with Nifuratel and Nysfungin Vaginal Soft Capsules in treatment of bacterial vaginosis. Methods Patients(150 cases) with bacterial vaginosis in Huangshi Central Hospital of Edong Medical Group from October 2015 to October 2017 were randomly divided into control and treatment groups, and each group had 75 cases. Patients in the control group were treated with Nifuratel and Nysfungin Vaginal Soft Capsules after cleaning the vulva before bedtime, one capsule was placed in the deep vagina, and repeated the above procedure after 24 h. Patients in the treatment group were po administered with Fuyanxiao Capsules on the basis of the control group, 3 grains/time, three times daily. A course of treatment had 7 d, and patients in two groups were treated for 2 courses. After treatment, the clinical efficacy was evaluated, and the improvement times of clinical signs, vaginal p H value, detection rate of lactobacillus and pathogenic bacteria, and the follow-up recurrence rate in two groups were compared. Results After treatment, the clinical efficacy in the control and treatment groups was 81.33% and 94.67%, respectively, and there were differences between two groups(P < 0.05). After treatment, the times of leucorrhea reduction, vulvar pruritus disappearance, vulvovaginal pain disappearance and mucosal congestion disappearance in the treatment group were significantly shorter than those in the control group, and there were differences between two groups(P < 0.05). After treatment, the vaginal pH value and detection rate of pathogenic bacteria in two groups were significantly decreased, but the detection rate of lactobacillus in two groups were significantly increased, and the difference was statistically significant in the same group(P < 0.05). After treatment, vaginal p H value, and detection rates of lactobacillus and pathogenic bacteria in the treatment group were significantly better than those in the control group, with significant difference betwee
作者
张青冬
尹红章
汪萍萍
潘春燕
ZHANG Qing-dong;Y1N Hong-zhang;WANG Ping-ping;PAN Chun-yan(Department of Obstetrics and Gynecology,Huangshi Central Hospital of Edong Medical Group (Affiliated Hospital of Hubei Polytechnic University),Huangshi 435000,China)
出处
《现代药物与临床》
CAS
2018年第12期3298-3301,共4页
Drugs & Clinic
关键词
妇炎消胶囊
硝呋太尔制霉菌素阴道软胶囊
细菌性阴道炎
阴道PH值
乳酸杆菌
病原菌
随访复发率
Fuyanxiao Capsules
Nifuratel and Nysfungin Vaginal Soft Capsules
bacterial vaginosis,vaginal pH value
lactobacillus
pathogenic bacteria
follow-up recurrence rate
