摘要
目的探究氟哌酸联合雌三醇治疗绝经女性泌尿生殖道感染的临床疗效及其对患者血清炎症因子和免疫球蛋白水平的影响。方法前瞻性选取2016年1月至2017年11月陕西省核工业二一五医院泌尿外科收治的绝经女性中泌尿生殖系统发生感染的患者80例作为研究对象,按随机数表法分为对照组和观察组,每组40例,对照组采用氟哌酸治疗,观察组采用氟哌酸联合雌三醇治疗,治疗4周。比较两组患者治疗前后的炎性因子与免疫球蛋白、治疗效果、不良事件及复发情况。结果观察组和对照组患者治疗后的炎症因子均显著下降,与治疗前比较差异均有统计学意义(P<0.05);治疗后,观察组患者的肿瘤坏死因子-α(TNF-α)、白细胞介素-6 (IL-6)、白细胞介素-8 (IL-8)分别为(101.42±13.66) ng/mL、(42.30±5.80) ng/mL、(116.44±15.75) ng/mL,明显低于对照组的(118.32±16.61) ng/mL、(58.46±7.76) ng/mL、(142.25±18.83) ng/mL,差异均有统计学意义(P<0.05);观察组和对照组患者治疗后的免疫球蛋白水平均显著升高,与治疗前比较差异均有统计学意义(P<0.05);治疗后,观察组患者免疫球蛋白免疫球蛋白G (IgG)、免疫球蛋白A (IgA)、免疫球蛋白M (IgM)水平分别为(8.96±1.28) g/L、(0.34±0.05) g/L、(0.78±0.13) g/L,明显高于对照组的(7.92±1.20) g/L、(0.29±0.10) g/L、(0.57±0.10) g/L,差异均有统计学意义(P<0.05);观察组和对照组患者治疗后的雌激素、子宫内膜厚度、健康状况评分均明显升高,与治疗前比较差异均有统计学意义(P<0.05);治疗后,观察组患者的雌激素、子宫内膜厚度、健康状况评分分别为(61.92±8.67) pmol/L、(3.73±0.51) mm、(12.91±1.91)分,明显高于对照组的(54.99±7.72) pmol/L、(3.47±0.63) mm、(9.77±1.36)分,差异均有统计学意义(P<0.05);观察组和对照组患者的阴道pH值和阴道炎症评分治疗后均明显下降,与治疗前比较差异均有统计学意义(P<0.05);治疗后,观察�
Objective To explore the clinical efficacy ofnorfloxacin combined with estradiol in the treatment of urogenital tract infection in postmenopausal women and its effect on serum inflammatory factors and immunoglobulin levels.Methods Prospective selection of 80 patients with urinary and reproductive system infection in postmenopausal women admitted to the Department of Urology at No.215 Hospital of Shaanxi Nuclear Industry from January 2016 to November 2017 were the study subjects.The patients were randomly divided into an observation group and a control group according to the random number table method,with 40 cases in each group.The control group was treated with norfloxacin,and the observation group was treated with norfloxacin combined with estriol;both courses of treatment were 4 weeks.The two groups were compared before and after treatment on the inflammatory factors and immune globulins,therapeutic effects,adverse events,and recurrence rate.Results Compared with before treatment,the inflammatory cytokines in the observation group and the control group were significantly decreased after treatment,and the difference was statistically significant (P<0.05).After treatment,the tumor necrosis factor-α(TNF-α),interleukin-6 (IL-6), and interleukin-8 (IL-8)in the observation group were respectively (101.42±13.66)ng/mL,(42.30±5.80)ng/mL and (116.44±15.75)ng/mL,which were significantly lower than corresponding (118.32±16.61)ng/mL,(58.46±7.76)ng/mL and (142.25±18.83)ng/mL in the control group;all differences were statistically significant (P<0.05).Compared with before treatment,the immunoglobulin levels in the observation group and the control group were significantly increased after treatment (P<0.05).After treatment,the levels of immunoglobulin G (IgG),immunoglobulin A rigA)and immunoglobulin M (IgM)in the observation group were respectively (8.96±1.28)g/L,(0.34±0.05)g/L and (0.78+0.13)g/L,which were significantly higher than corresponding (7.92±1.20)g/L,(0.29±0.10)g/L and (0.57±0.10)g/L in the control gro
作者
张建斌
李占琦
徐宝海
ZHANG Jian-bin;LI Zhan-qi;XU Bao-hai(Department of Urology,No.215 Hospital of Shaanxi Nuclear Industry,Xianyang 712000,Shaanxi,CHINA;Department of Urinary Surgery,Ankang Central Hospital,Ankang 725000,Shaanxi,CHINA)
出处
《海南医学》
CAS
2018年第24期3483-3486,共4页
Hainan Medical Journal
基金
陕西省科学计划项目(编号:2012K15-02)
关键词
氟哌酸
雌三醇
泌尿生殖道感染
雌激素
炎症因子
免疫球蛋白
疗效
Norfloxacin
Estradiol
Urogenital tract infection
Estrogen
Inflammatory cytokines
Immunoglobulin
Curative effect
