摘要
目的分析2型糖尿病(T2DM)合并尿路感染的病原菌分布、耐药性及相关因素,为感染预防和控制工作提供参考依据。方法选取2014年6月-2016年10月医院收治的T2DM患者502例作为研究对象,对患者尿路感染的发生率及相关因素进行观察和分析;对感染患者病原菌分布及耐药性进行检测。结果有126例患者发生尿路感染,感染率为25.1%;共分离出131株病原菌,以革兰阴性菌为主,共104株占79.4%;革兰阴性菌对氨苄西林、环丙沙星等药物的耐药率较高,未检出对亚胺培南耐药的菌株;logistic多元回归分析结果显示,患者年龄、住院天数、联合应用抗菌药物情况、入院空腹血糖水平、入院糖化血红蛋白水平、糖尿病病程是发生T2DM合并尿路感染的独立危险因素(P<0.05)。结论 T2DM患者合并尿路感染的病原菌分布、耐药性和相关因素具有一定的特点,临床医务人员应给予密切的监控和有效的干预,以达到提高感染防治效率、改善患者预后的目的。
OBJECTIVE To analyze the distribution and drug resistance of pathogenic bacteria and related factors in patients with type 2 diabetes mellitus（T2DM）complicated with urinary tract infections,so as to provide references for infection prevention and control.METHODS A total of 502 patients with T2DM from Jun.2014 to Oct.2016 were selected as the research subjects.The incidences and related factors of urinary tract infections in the patients were observed and analyzed.The distribution and drug resistance of the pathogenic bacteria in the infected patients were detected.RESULTS Totally 126 cases of patients were with urinary tract infections,and the infection rate was 25.1% .A total of 131 strains of bacteria were isolated.The main pathogens were 104 strains of gram-negative bacteria,accounting for 79.4% .The drug resistance rates of gram-negative bacteria to ampicillin and ciprofloxacin were high,and no straits resistant to imipenem were detected.Logistic regression analysis results showed that the age,hospitalization time,combined antimicrobial drugs application,fasting plasma glucose level,glycosylated hemoglobin level,and duration of diabetes were independent risk factors of T2DM complicated with urinary tract infection（P〈0.05）.CONCLUSIONThe distribution and drug resistance of pathogenic bacteria and the related factors in patients with T2DM complicated with urinary tract infection have certain characteristics.The clinical medical staff should apply close monitoring and effective interventions to improve the efficiency of infection prevention and treatment,so as to improve the prognosis of the patients.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2017年第15期3468-3471,共4页
Chinese Journal of Nosocomiology
关键词
2型糖尿病
尿路感染
病原菌分布
耐药性分析
相关因素分析
Type 2 diabetes mellitus
Urinary tract infection
Pathogen distribution
Drug resistance analysis
Related factors analysis
