摘要
目的分析胱抑素-C(CysC)、糖化血红蛋白(HbA1c)、超敏C-反应蛋白(hs-CRP)、β2-微球蛋白(β2-MG)联合检测在糖尿病患者早期肾损伤诊断中的临床意义。方法选取本院2018年1月至2020年6月收治的2型糖尿病伴肾损伤患者90例作为研究组,依据尿白蛋白排泄率将研究组患者分为研究Ⅰ组(n=40)和研究Ⅱ组(n=50),研究Ⅰ组为早期肾损伤组(300 mg/24 h≥尿白蛋白排泄率>30 mg/24 h),研究Ⅱ组为中晚期肾损伤组(尿白蛋白排泄率>300 mg/24 h),并选取同期来本院接受健康体检的50名健康体检者,将其作为对照组。比较各组CysC、HbA1c、hs-CRP以及β2-MG水平及阳性检测率。结果研究Ⅱ组各检测指标(CysC、HbA1c、hs-CRP以及β2-MG)均明显高于研究Ⅰ组、对照组(P<0.05),研究Ⅰ组各项检测指标均明显高于对照组(P<0.05)。研究Ⅱ组各指标单独检测、联合检测阳性率均明显高于研究Ⅰ组、对照组(P<0.05),研究Ⅰ组各项检测指标均明显高于对照组(P<0.05)。结论CysC、HbA1c、hs-CRP以及β2-MG能准确反映2型糖尿病患者疾病进展及早期肾损伤,联合检测各指标能为病情监测和临床指标提供科学依据,具有临床推广价值。
Objective To analyze the clinical significance of Cystatin-C(CysC),Glycosylated hemoglobin(HbA1c),high sensitive C-reactive protein(hs-CRP),β2-microglobulin(β2-GM)in the diagnosis of early renal injury in diabetic patients.Methods 90 patients with type 2 diabetes mellitus and renal injury admitted to our hospital from January 2018 to June 2020 were selected as the study group.According to the urinary albumin excretion rate,the study group was divided into study group I(n=40)and study group II(n=50).Study group I was the early renal injury group(300 mg/24 h≥urinary albumin excretion rate>30 mg/24 h),and study group II was the mid late renal injury group(urinary albumin excretion rate>300 mg/24 h).And select 50 healthy examinees who came to our hospital for health checkup in the same period as the control group.CysC,HbA1c,hs-CRP andβ2-MG were detected and compared among the different groups.Results The indexes of CysC,HbA1c,hs-CRP andβ2-MG in study group II were significantly higher than those in study group I and control group(P<0.05),and the indexes in study group I were significantly higher than those in control group(P<0.05).The positive rate of each index in study group II was significantly higher than that in study group I and control group(P<0.05),and the positive rate of each index in study group I was significantly higher than that in control group(P<0.05).Conclusion CysC,HbA1c,hs-CRP andβ2-MG can accurately reflect the disease progression and early renal injury in patients with type 2 diabetes mellitus,and the combined detection of each index can provide scientific basis for disease monitoring and clinical indicators,which has clinical value.
作者
张菁
刘惠芸
龚丹
Zhang Jing;Liu Huiyun;Gong Dan(Department of Clinical Laboratory,Jiangxi Integrated Hospital of Traditional Chinese andWestern Medicine,Nanchang,Jiangxi,330003,China;Department of Clinical Laboratory,Jiangxi Mental Hospital,Nanchang,Jiangxi,330006,China)
出处
《当代医学》
2020年第28期14-16,共3页
Contemporary Medicine
基金
江西省卫生健康委员会科技计划项目(20204041)。
