摘要
目的探究血清Cys-C与尿β_2-MG、kim-1、M-ALB联合检测在早期糖尿病肾病(DN)诊断中的应用。方法收集本院2015年11月~217年3月124例2型糖尿病患者,根据患者24 h尿微量白蛋白排泄率检查结果不同分NDN组(n=62)和DN组(n=62),另于同期选择58例健康体检者为对照组,均进行血清Cys-C、尿β_2-MG、尿kim-1、尿M-ALB等项目检测。结果 (1)DN组的血清Cys-C、尿β_2-MG、kim-1、M-ALB水平均显著优于NDN组、对照组(P<0.05);(2)血清Cys-C、尿β_2-MG、kim-1、M-ALB联合检测的灵敏度为90.32%、特异性95.16%、准确率92.74%、阳性预测值94.92%、阴性预测值90.77%,均明显高于任一项目单项检测的结果(P<0.05)。结论与单一项目检测相比,血清Cys-C与尿β_2-MG、kim-1、M-ALB联合检测的诊断价值更高,能够显著提高诊断准确率,成为早期DN诊断的主要方法。
Objective To explore the application of combined detection of serum Cys-C and urineβ_2-MG, KIM-1 and M-ALB in the diagnosis of early diabetic nephropathy（DN）. Methods From November 2015 to March 217, 124 patients with type 2 diabetes were selected in our hospital. According to the results of 24 h urine microalbumin excretion rate were divided into NDN group（n=62） and group DN（n=62）. At the same time, 58 healthy persons were selected as the control group. And all of them were detected for serum Cys-C, urine β_2-MG, urine KIM-1 and urine M-ALB.Results（1）The levels of serum Cys-C, urine β_2-MG, KIM-1 and M-ALB in group DN were significantly better than NDN group and control group（P0.05）.（2）The sensitivity of the combined detection was 90.32%,the specificity was 95.16%, the accuracy was 92.74%, the positive predictive value was 94.92%, and the negative predictive value was 90.77%,which were significantly higher than the results of single item test of any item（P 0.05）. Conclusion Compared with single detection, the combined detection of serum Cys-C and urinary β_2-MG, kim-1, M-ALB has higher diagnostic value, can significantly improve the diagnostic accuracy, and become the main method of early DN diagnosis.
作者
王绍文
高耀云
Wang Shaowen1, Gao Yaoyun2(1. Chidong Town Health Center at Qichun County, Qichun, Hubei, 435300, China; 2. Clinical Laboratory, Qichun County Matemal and Child Health Hospital, Qichun, Hubei, 435300, China)
出处
《当代医学》
2018年第19期100-102,共3页
Contemporary Medicine
