摘要
目的:观察清热护胃汤辅助治疗消化性溃疡对患者血清一氧化氮(NO)、白细胞介素-17(IL-17)及胃泌素(GAS)水平的影响。方法:将98例消化性溃疡患者采用系统随机化法分为观察组与对照组各49例,对照组予以常规西药治疗,观察组在此基础上予以清热护胃汤辅助治疗。比较两组患者治疗8周后的临床疗效及幽门螺杆菌(Hp)清除率,治疗前、治疗8周后消化道激素水平[胃动素(MTL)、胃泌素(GAS)、生长抑素(SS)]水平、血清炎症因子[一氧化氮(NO)、白细胞介素-17(IL-17)]胃排空功能(5h胃排空率)变化,以及6个月内复发情况。结果:治疗8周后,观察组治疗总有效率明显高于对照组,差异有统计学意义(P<0.05);治疗8周后,观察组患者Hp清除率为95.92%(47/49),高与对照组的75.51%(37/49),差异有统计学意义(P<0.05);治疗8周后,两组患者MTL、GAS水平均较治疗前降低,且观察组低于对照组,SS水平均较治疗前升高,且观察组高于对照组,差异均有统计学意义(P<0.05);治疗8周后,两组患者MTL、GAS水平均较治疗前降低,且观察组低于对照组,SS水平均较治疗前升高,且观察组高于对照组,差异均有统计学意义(P<0.05);治疗8周后,两组患者5h胃排空率均较治疗前升高,且观察组高于对照组,差异均有统计学意义(P<0.05);随访6个月,观察组病情复发率为8.16%(4/49),低于对照组的30.61%(15/49),差异有统计学意义(P<0.05)。结论:清热护胃汤辅助医治疗消化性溃疡可改善疗效,提高Hp清除率,抑制胃酸分泌,降低溃疡复发率。
Objective:To observe the effect of Qingre Huwei Decoction adjuvant therapy on levels of serum nitric oxide(NO),interleukin-17(IL-17)and gastrin(GAS)in patients with peptic ulcer.Methods:Ninety-eight patients with peptic ulcer were divided into observation group and controlled group according to the system randomization methods,with 49 cases in each group.The controlled group was treated with conventional western medicine,and the observation group was treated with Qingre Huwei Decoction adjuvant therapy on this basis.The clinical efficacy and helicobacter pylori(Hp)clearance rate after 8 weeks of treatment and gastrointestinal hormones levels[motilin(MTL),gastrin(GAS),somatostatin(SS)],serum inflammatory factors[nitric oxide(NO),interleukin-17(IL-17)]and gastric emptying function(5h gastric emptying rate)before treatment and after 8 weeks of treatment and recurrence within 6 months were compared between the two groups.Results:After 8 weeks of treatment,the total effective rate of treatment in the observation group was significantly higher than that in the controlled group(P<0.05).After 8 weeks of treatment,the Hp clearance rate in the observation group was higher than that in the controlled group[95.92%(47/49)vs 75.51%(37/49)](P<0.05).After 8 weeks of treatment,the levels of MTL and GAS in the two groups were lower than those before treatment,and the levels in the observation group were lower than those in the controlled group,and the SS level was higher than that before treatment,and the level in the observation group was higher than that in the controlled group(P<0.05).After 8 weeks of treatment,the levels of MTL and GAS in the two groups were lower than those before treatment,and the levels in the observation group were lower than those in the controlled group,and the SS level was higher than that before treatment,and the level in the observation group was higher than that in the controlled group(P<0.05).After 8 weeks of treatment,the 5h gastric emptying rate in the two groups was higher than that before treatm
作者
刘华
章一凡
LIU Hua;ZHANG Yifan(Yantai Affiliated Hospital of Binzhou Medical College,Binzhou Shandong 256600,China;Suzhou Hospital of Traditional Chinese Medicine,Suzhou Jiangsu 215000,China)
出处
《四川中医》
2020年第7期127-130,共4页
Journal of Sichuan of Traditional Chinese Medicine
