摘要
目的 研究埃索美拉唑联合克拉霉素治疗消化性溃疡的疗效及安全性。方法 60例消化性溃疡患者,随机分为对照组和观察组,每组30例。对照组患者仅接受克拉霉素治疗,观察组患者采用埃索美拉唑联合克拉霉素治疗。对比两组患者的临床治疗效果、不良反应发生情况、视觉模拟评分法(VAS)评分、幽门螺杆菌(Hp)根除率以及预后生活质量评分。结果 观察组患者的治疗总有效率为96.67%(29/30),明显高于对照组的73.33%(22/30),差异具有统计学意义(P<0.05)。观察组患者的不良反应发生率为6.67%,低于对照组的16.67%,但差异无统计学意义(P>0.05)。观察组患者治疗后第2、4、6天的VAS评分分别为(7.56±0.53)、(5.48±0.66)、(3.02±0.30)分,均明显低于对照组的(7.87±0.44)、(6.89±1.03)、(4.71±0.68)分,差异具有统计学意义(P<0.05)。观察组患者的Hp根除率为93.33%,明显高于对照组的70.00%,差异具有统计学意义(P<0.05)。观察组患者的物质生活、生理功能、心理功能、社会功能、总分分别为(60.15±8.53)、(60.59±8.19)、(75.26±10.57)、(76.75±9.53)、(68.23±8.58)分,均高于对照组的(48.23±8.81)、(48.52±8.32)、(60.31±11.71)、(61.54±9.32)、(58.65±6.32)分,差异具有统计学意义(P<0.05)。结论 消化性溃疡患者采用埃索美拉唑联合克拉霉素治疗的疗效确切, Hp的根除率较高,能有效改善患者的预后生活质量,且患者的腹痛能在最短时间内得到缓解,有利于患者尽早回归正常的生活和工作中,且两种药物联用不会增加患者的不良反应,安全性有所保障,临床上值得进行推广应用。
Objective To study the efficacy and safety of esomeprazole combined with clarithromycin in the treatment of peptic ulcer. Methods A total of 60 patients with peptic ulcer were randomly divided into control group and observation group, with 30 cases in each group. The control group was treated with clarithromycin, and the observation group was treated with esomeprazole combined with clarithromycin. The clinical effect, occurrence of adverse reactions, visual analogue scale(VAS) score, Helicobacter pylori(Hp) eradication rate and prognosis quality of life score were compared between the two groups. Results The total effective rate in the observation group was 96.67%(29/30), which was significantly higher than 73.33%(22/30) in the control group, and the difference was statistically significant(P<0.05). The incidence of adverse reactions in the observation group was 6.67%, which was lower than 16.67% in the control group, but the difference was not statistically significant(P>0.05). The VAS scores of the observation group on the 2nd, 4th, and 6th days after treatment were(7.56±0.53),(5.48±0.66), and(3.02±0.30) points, which were significantly lower than(7.87±0.44),(6.89±1.03), and(4.71±0.68) points of the control group, and the differences were statistically significant(P<0.05). The Hp eradication rate in the observation group was 93.33%, which was significantly higher than 70.00% in the control group, and the difference was statistically significant(P<0.05). The material life, physiological function,psychological function, social function and total scores in the observation group were(60.15±8.53),(60.59±8.19),(75.26±10.57),(76.75±9.53), and(68.23±8.58) points, which were higher than(48.23±8.81),(48.52±8.32),(60.31±11.71),(61.54±9.32), and(58.65±6.32) points in the control group, and the differences were statistically significant(P<0.05). Conclusion Esomeprazole combined with clarithromycin is effective in the treatment of patients with peptic ulcer. The eradication rate of Hp is high, which can effec
作者
谭广山
石磊
TAN Guang-shan;SHI Lei(Department of Pharmacy,Liaocheng People's Hospital,Liaocheng 252000,China)
出处
《中国实用医药》
2022年第18期11-14,共4页
China Practical Medicine
