摘要
目的 探讨消化性溃疡(PU)患者采用质子泵抑制剂治疗对临床疗效及过氧化脂质(LPO)、C反应蛋白(CRP)水平的影响.方法 选取2019年1月-2022年1月金溪县中医院收治的PU患者共计60例,根据随机摸球法分成治疗组(n=30)与对照组(n=30),对照组采用常规治疗,给予止血、补血、吸氧、营养支持等,治疗组采用质子泵抑制剂治疗,对两组临床疗效、LPO、CRP水平、免疫功能、症状评分及不良反应进行比较.结果 治疗组总有效率(93.33%)较对照组(70.00%)明显更高(P<0.05);治疗后两组LPO、CRP水平均明显降低(P<0.05),治疗组水平较对照组明显更低(P<0.05);治疗后两组CD4^(+)、CD4^(+)/CD8^(+)明显提高(P<0.05),CD8^(+)明显降低(P<0.05),治疗组CD4^(+)、CD4^(+)/CD8^(+)较对照组明显更高(P<0.05),CD8^(+)较对照组明显更低(P<0.05);治疗后两组腹痛、腹胀、呕血、黑便评分明显降低(P<0.05),治疗组较对照组明显更低(P<0.05);治疗组不良反应发生率(6.67%)较对照组(33.33%)明显更低(P<0.05).结论 质子泵抑制剂治疗应用于PU患者,能够提高临床疗效,降低LPO、CRP水平,改善免疫功能及临床症状,减少不良反应.
Objective To investigate the effect of proton pump inhibitors(PPIs)on the clinical efficacy and the levels of lipid peroxide(LPO)and C-reactive protein(CRP)in patients with peptic ulcer(PU).Methods A total of 60 patients with PU treated in our hospital from January 2019 to January 2022 were randomly divided into treatment group(n=30)and control group(n=30)according to the method of touching the ball.The control group was treated with routine treatment,including hemostasis,blood tonifying,oxygen inhalation and nutritional support.The treatment group was treated with proton pump inhibitors.The clinical efficacy,LPO,CRP levels,immune function,symptom score and adverse reactions of the two groups were compared.Results The total effective rate of the treatment group(93.33%)was significantly higher than that of the control group(70.00%)(P<0.05);after treatment,the levels of LPO and CRP in the treatment group were significantly lower than those in the control group(P<0.05);after treatment,CD4^(+)and CD4^(+)/CD8^(+)in the two groups were significantly increased(P<0.05),and CD8 was significantly decreased(P<0.05).CD4^(+),CD4^(+)/CD8^(+)in the treatment group were significantly higher than those in the control group(P<0.05),and CD8^(+)was significantly lower than those in the control group(P<0.05);after treatment,the scores of abdominal pain,abdominal distension,hematemesis and black stool in the treatment group were significantly lower than those in the control group(P<0.05);the incidence of adverse reactions in the treatment group(6.67%)was significantly lower than that in the control group(33.33%)(P<0.05).Conc lusion Proton pump inhibitors can improve the clinical efficacy,reduce the levels of LPO and CRP,improve immune function and clinical symptoms,and reduce adverse reactions in Pupatients.
作者
卢杜丹
Lu Dudan(Departmentof internal medicine,Jinxi County Hospital of traditional Chinese medicine,Fuzhou,Jiangxi 344800,China)
出处
《首都食品与医药》
2022年第22期80-83,共4页
Capital Food Medicine
