摘要
目的:归纳总结幼年黄色肉芽肿的临床及组织病理特点。方法:回顾性分析2011年12月—2019年12月我院确诊的32例幼年黄色肉芽肿患儿的临床资料和组织病理学检查结果。结果:32例患儿皮损多表现为头面部、躯干、四肢黄色或黄褐色丘疹、结节,也可表现为红色或暗红色,有1例伴皮肤外症状。皮损组织病理特点可分为3种类型:早期(占12.50%),可见大量组织细胞浸润,散在多核巨细胞、淋巴细胞、少量嗜酸性细胞浸润;成熟期(占78.12%),可见典型泡沫细胞、多核巨细胞及Touton巨细胞;消退期(占9.38%),可见梭形细胞,少许组织细胞及多核巨细胞。免疫组化结果为CD68(+)、CD1a(-)、Langerin(-)及S-100(-)。结论:临床上根据典型皮损特点及病理表现一般可诊断幼年黄色肉芽肿,但临床上有必要行病理检查以帮助减少误诊率。
Objective:To summarize the clinical and histopathological features of juvenile xanthogranuloma(JXG).Methods:The clinical manifestations and histopathological findings of 32 children with juvenile xanthogranuloma diagnosed and treated in our hospital from December 2011 to December 2019 were retrospectively analyzed.Results:The lesions were yellow or tawny,also red or dark red,papules and nodules on the head,face,trunk or limbs.There was a case with external skin symptoms.Histopathological features can be divided into three types:early juvenile xanthogranuloma(12.50%),the pathology showed a large number of histocytes infiltration,with scattered multinucleate giant cells,lymphocytes,and eosinophilic cells;mature juvenile xanthogranuloma(78.12%),the pathology showed typical foam cells,multinucleated giant cells and typical Touton giant cells;transitional juvenile xanthogranuloma(9.38%),the pathology showed spindle-shaped cells,histocytes and multinucleated giant cells.Immunohistochemical results were CD68(+),CD1 a(-),Langerin(-)and S-100(-).Conclusion:The diagnosis of JXG can be made according to the typical skin lesion characteristics and pathological findings,while pathological examination is necessary to reduce the misdiagnosis rate.
作者
胡翠
李巍
鲁慧
顾洋
钱莹莹
伍博
钱华
HU Cui;LI Wei;LU Hui;GU Yang;QIAN Ying-ying;WU Bo;QIAN Hua(Department of Dermatology,Children's Hospital of Soochow University,Suzhou 215025,China)
出处
《皮肤性病诊疗学杂志》
2020年第4期232-236,共5页
Journal of Diagnosis and Therapy on Dermato-venereology
基金
苏州市科技局项目(编号:SYS201644)。
关键词
幼年黄色肉芽肿
临床表现
组织病理
免疫组化
juvenile xanthogranuloma
clinical manifestations
histological features
immunohistochemistry
