摘要
目的探究硫酸特布他林雾化溶液联合更昔洛韦(Ganciclovir,GCV)对巨细胞病毒感染性(Cytomegalovirus infectivity,CMV)肺炎患儿的疗效及对血清C-反应蛋白(CRP)、肿瘤坏死因子(TNF-α)、白细胞介素-6(IL-6)、IL-8水平的影响。方法选取南昌市第三医院2017年2月-2018年2月儿内科收治的CMV肺炎患儿85例为研究对象,随机分为研究组43例和对照组42例。研究组在常规治疗及对照组基础上加用硫酸特布他林雾化溶液联合GCV治疗,对照组在常规治疗基础上加用GCV抗病毒治疗。比较两组患者的临床疗效、临床症状消失时间及住院时间、血清细胞因子TNF-α、IL-6、IL-8、CPR。结果研究组疗效优于对照组(P=0.030);研究组临床症状消失时间和住院时间分别为(12.36±4.27)h和(5.15±2.15)d均短于对照组(P<0.05);两组患者治疗后的TNF-α、IL-6、IL-8、CPR均低于治疗前(P<0.05),且研究组以上指标分别为(17.25±9.45)ng/L、(8.12±3.18)ng/L、(18.38±3.58)mg/L、(2.34±1.19)μg/L低于对照组(P<0.001);研究组的不良反应总发生率为4.65%(2/43)低于对照组(P=0.049)。结论硫酸特布他林雾化溶液联合更昔洛韦能减少患者的炎症反应、降低不良反应发生率,对病毒感染性肺炎患儿具有较好的临床疗效。
OBJECTIVE To investigate the effect of terbutaline sulfate aerosol solution combined with ganciclovir on children with cytomegalovirus-infected(CMV)pneumonia and the influence of serum levels of C-reactive protein,tumor necrosis factor-α,interleukin-6 and interleukin-8.METHODS A total of 85 children with CMV pneumonia admitted to department of Pediatrics of Nanchang Third Hospital between Feb.2017 and Feb.2018 were selected as the research subjects and randomly divided into the study group 43 cases and the control group of 42 cases.The study group was treated with terbutaline sulfate aerosol solution combined with GCV on the basis of routine treatment,while the control group was treated with GCV antiviral therapy on the basis of conventional treatment.The clinical curative efficacy,disappearance time of clinical symptoms and hospitalization time,changes of serum levels of TNF-α,IL-6,IL-8 and CPR were compared between the two groups.RESULTS The curative efficacy of the study group was significantly better than that of the control group(P=0.030).The time to disappearance of clinical symptoms and the length of hospital stay in the study group were(12.36±4.27)h and(5.15±2.15)d,respectively,significantly shorter than those in the control group(P<0.05).After treatment,TNF-α,IL-6,IL-8,and CPR were significantly lower in the two groups than before treatment(P<0.05),and the above indicators in the study group were(17.25±9.45)ng/L,(8.12±3.18)ng/L,(18.38±3.58)mg/L,(2.34±1.19)μg/L,respectively,significantly lower than the control group(P<0.001).The total incidence of adverse reactions in the research group was 4.65%(2/43),significantly lower than the control group(P=0.049).CONCLUSION Terbutaline sulfate aerosol solution combined with ganciclovir can reduce the incidence of inflammatory reaction and adverse reactions in children with viral pneumonia,and has a good clinical effect on children with viral pneumonia.
作者
万方锐
吴冬
章燕燕
王淑云
WAN Fang-rui;WU Dong;ZHANG Yan-yan;WANG Shu-yun(The Third Hospital of Nanchang,Nanchang,Jiangxi 330009,China)
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2020年第11期1741-1744,共4页
Chinese Journal of Nosocomiology
基金
江西省基层卫生适宜技术“星火推广计划”基金资助项目(20158010)。
