摘要
目的通过计算流体动力学(computational fluid dynamics,CFD)分析右冠状动脉起源于左冠状窦(anomalous origin of the right coronary artery from the left coronary artery sinus,AORL)的血流动力学参数,从而有效评估疾病。方法选取正常右冠状动脉(right coronary artery,RCA)和AORL两例个体病例,在Mimics软件中重建两个病例的血管模型,并将模型导入ANSYS CFX软件中进行血流动力学模拟计算,比较正常和AORL两种模型的血流动力学情况。结果AORL模型右冠状动脉入口截面具有较小的血流量(9.35 cm^3/s),有可能会导致右冠状动脉下游供血不足;AORL模型右冠状动脉急性拐角处的压力(13.78 kPa)相比于正常模型右冠状动脉(14.9 kPa)较低;AORL模型壁面剪切力(12.83 Pa)大于正常模型(9.74 Pa);AORL模型血管壁变形量较大。结论AORL入口流速及拐角处压力均比正常RCA小,从而可能导致缺血症状发生。研究结果对临床上有效评估缺血等疾病具有理论指导意义。
Objective To analyze the hemodynamic parameters of anomalous origin of the right coronary artery from the left coronary artery sinus(AORL)based on computational fluid dynamics(CFD),so as to make an evaluation of the disease.Methods A normal right coronary artery(RCA)case and an AORL case were selected.Two models were reconstructed in Mimics software and imported into ANSYS CFX software for hemodynamics simulation.The hemodynamics of normal RCA model and AORL model were compared.Results AORL model had a smaller volume flow(9.35 cm^3/s),which might lead to insufficient blood supply downstream of the RCA;the pressure at the acute corner of AORL model(13.78 kPa)was lower than normal RCA model(14.9 kPa);the wall shear stress(WSS)of AORL model(12.83 Pa)was larger than that of normal RCA model(9.74 Pa);the total deformation of AORL model was relatively large.Conclusions The entrance velocity and pressure of AORL were lower than those of normal RCA,which might lead to ischemic symptoms.The research findings are of theoretical significance for the effective evaluation of ischemia and other diseases in clinic.
作者
丛梦杨
赵慧慧
许星明
代顺
陈传智
邱建峰
钱秀清
秦升学
CONG Mengyang;ZHAO Huihui;XU Xingming;DAI Shun;CHEN Chuanzhi;QIU Jianfeng;QIAN Xiuqing;QIN Shengxue(College of Mechanical and Electronic Engineering,Shandong University of Science and Technology,Qingdao 266590,Shandong,China;College of Radiology,Shandong First Medical University&Shandong Academy of Medical Sciences,Taian 271016,Shandong,China;Center for Medical Engineer Technology Research,Shandong First Medical University&Shandong Academy of Medical Sciences,Taian 271016,Shandong,China;College of Mechanical and Electronic Engineering,Shandong University of Science and Technology,Taian 271016,Shandong,China;Department of Radiology,Tong Ren Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200336,China;Department of Radiology,Shanghai East Hospital,Shanghai 200120,China;Department of Biomedical Engineering,Capital Medical University,Beijing 100069,China)
出处
《医用生物力学》
EI
CAS
CSCD
北大核心
2020年第3期284-288,共5页
Journal of Medical Biomechanics
基金
山东省泰山学者项目(ts201712065)。
关键词
右冠状动脉
左冠状窦
血流动力学
血流速度
压力
壁面剪切力
right coronary artery(RCA)
left coronary artery sinus
hemodynamics
flow velocity
pressure
wall shear stress(WSS)
