摘要
背景:研究表明,维医沙疗对降低股动脉粥样硬化及血栓形成有一定的积极作用。 目的:通过对比沙疗前后 4 种狭窄模型的血流速度以及壁面切应力,研究沙疗对股动脉分叉管不同狭窄模型 的血流动力学参数的影响。 方法:研究方案的实施符合新疆大学机械工程学院对研究的相关伦理要求,受者均对试验过程完全知情同意。 采用医用软件 Mimics10.01、逆向工程软件 Geomagic Studio 2012 与三维 CAD 软件 UG 8.5 将 1 名受试者 的下肢 CT 数据进行分离、优化,得到人体股动脉分叉血管几何模型。依照下肢股动脉粥样硬化斑块所致的 血管狭窄分级标准,将位于股动脉分叉管侧壁的斑块狭窄程度分别设置为 0%(正常)、15%(正常)、30%(轻度) 和 50%(中度)。运用计算流体力学(CFD)方法进行数值模拟仿真,沙疗前血液流态选择 Laminar 层流模型, 沙疗后血液选择标准 κ-ε 紊流模型,进行沙疗前后血流速度和壁面切应力分析。 结果与结论:①沙疗后的血流最大速度较沙疗前增大了 0.35-0.45 m/s;②沙疗后动脉狭窄处的壁面切应力较 沙疗前增大了 5-11 Pa,50%狭窄率模型中狭窄处的壁面切应力达到了 41 Pa;③结果说明,沙疗后动脉粥 样硬化斑块扩大的趋势有所减弱,但 50%(中度)以上狭窄率的患者沙疗后有斑块破裂的危险。
BACKGROUND: Sand therapy has been shown to exhibit a positive effect on reducing femoral atherosclerosis and inhibiting thrombosis. OBJECTIVE: To investigate the effects of sand therapy on hemodynamic parameters of different stenosis models of femoral bifurcation through comparing the hemodynamic parameters and wall shear stress in four stenosis models before and after sand therapy. METHODS: The study protocol was performed in strict accordance with the relevant ethical requirements of School of Mechanical Engineering of Xinjiang University. Each participant provided written informed consent. Medical software Mimics10.01, reverse engineering software Geomagic Studio 2012 and three-dimensional CAD software UG8.5 were used to separate and optimize the CT data of a subject’s lower extremities and the geometric model of the femoral artery bifurcation was obtained. According to the classification criteria of vascular stenosis caused by femoral atherosclerotic plaque in the lower extremity, the degree of plaque stenosis on the side wall of the femoral bifurcation tube was set as 0% (normal), 15% (normal), 30% (mild) and 50% (moderate). Computational fluid dynamics method was used for numerical simulation. The Laminar flow model was selected for blood flow before sand therapy, and the standard turbulence model κ-ε was selected for blood flow after sand therapy. Blood flow velocity and wall shear stress were analyzed before and after sand therapy. RESULTS AND CONCLUSION: The maximum blood flow velocity after sand therapy was 0.35-0.45 m/s higher than that before sand therapy. After sand therapy, the wall shear stress at the stenosis was increased by 5-11 Pa compared with that before sand therapy, and the wall shear stress at 50% vascular stenosis rate model reached 41 Pa. These results suggest that the trend of atherosclerotic plaque enlargement is decreased after sand therapy, but patients with 50% (moderate) vascular stenosis have the risk of plaque rupture.
作者
乔钰淇
富荣昌
章立红
Qiao Yuqi;Fu Rongchang;Zhang Lihong(School of Mechanical Engineering,Xinjiang University,Urumqi 830047,Xinjiang Uygur Autonomous Region,China)
出处
《中国组织工程研究》
CAS
北大核心
2020年第8期1218-1224,共7页
Chinese Journal of Tissue Engineering Research
基金
国家自然科学基金（31460245），项目负责人：富荣昌~~
关键词
沙疗
股动脉
动脉粥样硬化性狭窄
血流动力学
计算流体力学
血流速度
壁面切应力
sand therapy
femoral artery
atherosclerotic stenosis
hemodynamics
computational fluid dynamics
blood flow velocity
wall shear stress
