摘要
胆盐水解酶(bile salt hydrolase,BSH)是微生物生长、繁殖过程中产生的一种代谢产物,该酶具有降解结合胆盐的能力。大量研究发现,益生菌可通过BSH来提高其在肠道中的存活率和稳定性,还能通过BSH参与胆汁酸调控而实现其部分益生功能,如降胆固醇等,因此益生菌BSH一直是研究的热点。为深入了解BSH,该文对BSH特性、在益生菌中的分布、生理功能以及对益生菌降低胆固醇、缓解炎症性肠病等方面发挥的作用进行了综述,期望为产BSH的益生菌在食品、保健品及临床应用提供理论依据。
Bile salt hydrolase(BSH)is a kind of metabolite,which is produced by microorganisms during the period of growth and reproduction.This enzyme has the ability to catalyzes hydrolysis of conjugated bile salts into amino acid and bile acids.A number of studies have shown that probiotics can increase the survival rate and stability in the intestine through BSH.Moreover,probiotics can achieve part of potential health-promoting functions by BSH participating in the regulation of bile acids,such as cholesterol lowering.Therefore,BSH in probiotics has always been a research hotspot.In order to understand BSH deeply,this article mainly reviewed the research progress on characteristics,distribution,physiological functions,and its role in reducing cholesterol and alleviating inflammatory bowel disease,aiming at providing theoretical basis in food,Health products and clinical applications of BSH-producing probiotics.
作者
唐洪玉
宋馨
夏永军
艾连中
王光强
TANG Hongyu;SONG Xin;XIA Yongjun;AI Lianzhong;WANG Guangqiang(Shanghai Engineering Research Center of Food Microbiology,School of Medical Instrument and Food Engineering,University of Shanghai for Science and Technology,Shanghai 200093,China)
出处
《食品与发酵工业》
CAS
CSCD
北大核心
2020年第13期286-292,共7页
Food and Fermentation Industries
基金
国家重点研发计划项目(2018YFD0501600)
上海市科技兴农项目(2019-02-08-00-07-F01152)。
关键词
益生菌
胆盐水解酶
胆固醇
肠炎
probiotics
bile salt hydrolase
cholesterol
enteritis
