摘要
目的观察针药并用联合康复训练治疗儿童孤独症的临床疗效及对血清白细胞介素-17(IL-17)水平的影响。方法儿童孤独症患者82例,采用随机数字法分为观察组和对照组,每组41例。对照组给予综合康复训练联合针刺治疗,观察组在对照组治疗基础上给予中药口服辨证治疗。观察两组治疗前后患者儿童孤独症行为量表(ABC)评分、文兰适应行为量表(VABS)评分及血清白细胞介素-17(IL-17)、白细胞介素-1β(IL-1β)、组织型纤溶酶原激活剂(t-PA)水平变化,并比较两组临床疗效。结果观察组总有效率为87.8%,对照组为68.3%,观察组患者总有效率高于对照组(P<0.05)。观察组治疗后VABS评分高于对照组,ABC评分低于对照组,差异具有统计学意义(P<0.05)。观察组治疗后t-PA水平高于对照组,IL-17、IL-1β水平低于对照组(P<0.05)。观察组不良反应率(7.3%)与对照组(4.9%)比较,差异无统计学意义(P>0.05)。结论针药并用联合康复训练治疗儿童孤独症疗效显著,可调节患者血清IL-17、IL-1β、t-PA的表达水平,提高社会适应及生存能力,且安全性高。
Objective To observe the clinical efficacy of acupuncture plus medication and rehabilitation in treating childhood autism and its effect on the level of serum interleukin(IL)-17. Method Eighty-two patients with childhood autism were divided into an observation group and a control group using the random number table method, with 41 cases in each group. The control group was given comprehensive rehabilitation training plus acupuncture treatment, based on which the observation group was given syndrome-differentiation treatment with oral Chinese medication. Before and after treatment, the Autism Behavior Checklist(ABC) score, Vineland Adaptive Behavior Scales(VABS) score and the levels of serum IL-17, IL-1β and tissue plasminogen activator(t-PA) were observed in the two groups. The clinical efficacy was also compared between the two groups. Result The total effective rate was 87.8% in the observation group versus 68.3% in the control group, and the total effective rate in the observation group was higher than that in the control group(P<0.05). After treatment, the VABS score was higher in the observation group than in the control group, and the ABC score was lower in the observation group than in the control group, both with statistical significance(P<0.05). After treatment, the level of t-PA was higher in the observation group than in the control group, and the levels of IL-17 and IL-1β were lower in the observation group than in the control group(P<0.05). There was no statistical significance comparing the adverse reaction rate between the observation group(7.3%) and the control group(4.9%)(P>0.05). Conclusion Acupuncture combined with medication and rehabilitation training can produce significant efficacy in treating childhood autism. It can regulate the expression levels of serum IL-17, IL-1β and t-PA, and enhance the social adaptive and living abilities, with high safety assessment.
作者
李华伟
党伟利
李伟
LI Hua-wei;DANG Wei-li;LI Wei(The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China)
出处
《上海针灸杂志》
2020年第7期861-865,共5页
Shanghai Journal of Acupuncture and Moxibustion
基金
河南省中医药科学研究专项课题(2018JDZX086)。
