摘要
目的:探讨健脾和胃法论治自闭症患儿肠道微生物的临床研究。方法:将2016年1月—2018年12月本院116例自闭症患儿,随机分两组,试验组与对照组,各58例,均采用相同的治疗原则,对照组采用双歧杆菌乳杆菌三联活菌片温开水冲服,1.5 g/次,每天3次;在此基础上,试验组采用健脾和胃法(白术10 g,干姜3 g,党参10 g,炙甘草10 g,乌梅3 g,大黄1 g)论治,每日1剂,治疗时间均为3个月。比较两组患儿的临床疗效,治疗前后分别记录孤独行为评定量表(ABC)、儿童孤独症评定量表(CARS)、肠道微生物及胶质细胞源性神经营养因子(GDNF)、S100β蛋白,记录不良反应状况。结果:对照组有效率77.59%低于试验组有效率91.38%,差异有统计学意义(P<0.05)。两组患儿治疗前ABC评分、CARS评分、肠道双歧杆菌、乳酸杆菌、肠杆菌、血清GDNF、S100β蛋白比较,差异无统计学意义(P>0.05)。治疗后对照组和试验组ABC评分为67.31±6.03、62.08±5.94,CARS评分为35.20±4.41、31.67±4.25,双歧杆菌为8.17±1.10、9.13±1.24,乳酸杆菌为9.24±1.23、10.15±1.31,肠杆菌为7.72±1.05、8.89±1.17,血清GDNF为(558.33±67.49)pg/m L、(517.37±64.17)pg/m L,血清S100β蛋白为(274.61±25.50)ng/m L、(256.31±24.15)ng/m L,对照组和试验组上述指标比较,差异有统计学意义(P<0.05)。结论:健脾和胃法论治自闭症患儿的疗效显著,可改善孤独症状和肠道微生物指标,降低血GDNF、S100β蛋白,患儿可耐受。
Objective:To explore the clinical effect of spleen-invigorating and stomach-invigorating therapy in the treatment of children with autism on intestinal microorganisms.Methods:A total of 116 children with autism in our hospital from January2016 to December 2018 were randomly divided into the experimental group and the control group,58 cases in each.Two groups adopted the same treatment principle,and the control group received warm boiled water with Bifidobacterium Lactobacillus triple viable tablets,1.5 g,three times a day,and the experimental group additionally received spleen-strengthening and stomach-strengthening methods,1 dose per day,and two groups were treated for 3 months.The clinical efficacy of the two groups was compared.The autism behavior rating scale(ABC),children autism rating scale(CARS),intestinal microorganisms and glial cell-derived neurotrophic factor(GDNF),S100 beta protein were recorded before and after treatment,and the adverse reactions were recorded.Results:The effective rate of the control group(77.59%)was lower than the experimental group’s 91.38%(P<0.05).There were no significant difference in ABC score,CARS score,intestinal bifidobacterium,lactobacillus,enterobacter,serum GDNF or S100 beta protein between the two groups before treatment(P>0.05).After treatment,the ABC scores of the control group and the experimental group were 67.31±6.03 and 62.08±5.94,the CARS scores were 35.20±4.41,and 31.67±4.25,the bifidobacteria scores were 8.17±1.10 and 9.13±1.24,the Lactobacillus scores were 9.24±1.23 and 10.15±1.31,the enterobacteria scores were 7.72±1.05 and 8.89±1.17,the serum GDNF scores were(558.33±67.49)pg/m L and(517.37±64.17)pg/m L,the levels of serum S100 beta protein were(274.61±25.50)ng/m L and(256.31±24.15)ng/m L,there were significant difference between the control group and the experimental group(P<0.05).Conclusion:Spleen-invigorating and stomach-invigorating therapy is effective in treating autism children.It can improve the symptoms of autism and intestinal microb
作者
宫凤英
李永春
林锦韬
成云水
高瑞娇
吕英
GONG Fengying;LI Yongchun;LIN Jintao;CHENG Yunshui;GAO Ruijiao;LYU Ying(Department of Ancient Chinese Medicine,Southern Hospital,Southern Medical University,Guangzhou 510515,Guangdong,China)
出处
《辽宁中医杂志》
CAS
2019年第12期2612-2615,共4页
Liaoning Journal of Traditional Chinese Medicine
基金
广东省中医药局科研项目(20191224)
广东省中医药局科研项目(20161155)
国家自然科学基金面上项目(81673718)
广东省自然科学基金项目(2016A030313833).
关键词
健脾和胃法
自闭症患儿
肠道微生物
GDNF
S100Β蛋白
invigorating spleen and stomach
autistic children
intestinal microorganisms
GDNF
S100beta protein
