摘要
目的对急性加重期COPD患者采取N-乙酰半胱氨酸治疗,并分析应用效果。方法便利选取2017年10月-2019年9月在该院治疗的84例急性加重期COPD患者,将其分为两组。对照组42例,接受常规治疗措施;观察组42例,在此基础上,采取N-乙酰半胱氨酸治疗。结果观察组患者的总有效率为95.24%,对照组为80.95%,差异有统计学意义(χ^2=4.09,P<0.05);治疗后,观察组患者的SOD水平明显高于对照组,MDA水平明显低于对照组(P<0.05),且观察组患者的FEV1%、FEV1/FVC水平明显高于对照组,IL-8、TNF-α水平明显低于对照组(P<0.05)。结论对急性加重期COPD患者采取N-乙酰半胱氨酸治疗可提高临床疗效,减轻患者氧化应激反应及炎症反应,改善患者肺功能。
Objective To treat patients with acute exacerbation of COPD by N-acetylcysteine and analyze the effect of application.Methods From October 2017 to September 2019,84 patients with acute exacerbation COPD treated in the hospital were conveniently selected and divided into two groups.In the control group,42 patients received conventional treatment measures;in the observation group,42 patients were treated with N-acetylcysteine.Results The total effective rate was 95.24%in the observation group and 80.95%in the control group.The difference was statistically significant(χ^2=4.09,P<0.05).After treatment,the SOD level in the observation group was significantly higher than the control group,and the MDA level was significantly lower In the control group(P<0.05),the levels of FEV1%,FEV1/FVC in the observation group were significantly higher than those in the control group,and the levels of IL-8 and TNF-αwere significantly lower than in the control group(P<0.05).Conclusion N-acetylcysteine treatment in patients with acute exacerbation COPD can improve clinical efficacy,reduce oxidative stress and inflammatory responses,and improve lung function in patients.
作者
陈军
CHEN Jun(Department of Geriatrics,Jiangsu North People's Hospital,Yangzhou,Jiangsu Province,225001 China)
出处
《中外医疗》
2020年第13期55-57,共3页
China & Foreign Medical Treatment
关键词
急性加重期
慢性阻塞性肺疾病
N-乙酰半胱氨酸
Acute exacerbation period
Chronic obstructive pulmonary disease
N-acetylcysteine
