摘要
目的:探讨卡介菌多糖核酸对中重度稳定期慢性阻塞性肺疾病患者免疫功能及血清炎性因子水平的影响。方法:选取2015年1月至2017年9月萍乡市第三人民医院收治的中重度稳定期慢性阻塞性肺疾病患者72例作为研究对象,采用简单随机化法分为观察组和对照组,每组36例。对照组患者给予长效β受体激动剂等常规治疗,观察组患者在对照组的基础上加用卡介菌多糖核酸肌内注射。治疗3个月后,观察两组患者血清炎性因子水平[白细胞介素8(IL-8)、肿瘤坏死因子α(TNF-α)]、免疫功能指标水平[免疫球蛋白A(IgA)、免疫球蛋白G(IgG)及免疫球蛋白M(IgM)]的变化。结果:治疗后,观察组患者IgA、IgG及IgM水平明显高于治疗前及对照组治疗后,差异均有统计学意义(P<0.05);治疗后,观察组患者IL-8、TNF-α水平明显低于治疗前及对照组治疗后,差异均有统计学意义(P<0.05)。结论:卡介菌多糖核酸肌内注射能显著增强中重度稳定期慢性阻塞性肺疾病患者的免疫功能,降低血清炎性因子水平,减轻炎症反应,有助于改善患者预后。
OBJECTIVE： To probe into the effects of BCG polysaccharide nucleic acid on immune function and serum inflammatory factor level in patients with moderate and severe chronic obstructive pulmonary disease（ COPD）.METHODS： 72 patients with moderate and severe COPD admitted into Pingxiang the Third People＇s Hospital from Jan.2015 to Sept. 2017 were extracted to be divided into observation group and control group via the simple randomization method,with 36 cases in each. The control group was given routine treatment such as long-acting β-receptor agonist,while the observation group additionally received BCG polysaccharide nucleic acid injection on the basis of the control group. After treatment of 3 months,changes of the serum inflammatory factor level[IL-8 and TNF-α ] and immune function index level[IgA,IgG and IgM]of two groups were observed. RESULTS： After treatment,the levels of IgA,IgG and IgM of observation group were significantly higher than those of before treatment and control group after treatment,with statistically significant difference（ P〈0. 05）. After treatment,the levels of IL-8 and TNF-α of observation group were significantly lower than those of before treatment and control group after treatment,with statistically significant difference（ P〈0. 05）. CONCLUSIONS： BCG polysaccharide nucleic acid injection can significantly improve the immune function in patients with moderate and severe COPD,reduce serum inflammatory factor level,reduce inflammation and help to improve the prognosis of patients.
作者
李鹰
魏尤良
王祖康
LI Ying;WEI Youliang;WANG Zukang(Dept.of Respiratory,Pingxiang the Third People＇s Hospital,Jiangxi Pingxiang 337055,Chin)
出处
《中国医院用药评价与分析》
2018年第6期798-799,802,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
慢性阻塞性肺疾病
中重度稳定期
卡介菌多糖核酸
免疫功能
炎性因子
Chronic obstructive pulmonary disease
Moderate to severe stability
BCG polysaccharide nucleicacid
Immune Function
Inflammatory factor
