摘要
①目的比较N-乙酰半胱氨酸(N-acetylcysteine,NAC)不同用药方式在治疗慢性阻塞性肺疾病急性加重期(Acute exacerbation of chronic obstructive pulmonary disease,AECOPD)患者的临床疗效。②方法选取华北理工大学附属医院收治的AECOPD患者64例,应用随机数字表法将患者分为雾化组 32例、口服组 32例。入组患者在抗炎、平喘等综合治疗的基础上分别给予吸入用乙酰半胱氨酸溶液雾化吸入、乙酰半胱氨酸泡腾片泡水口服。对比雾化组与口服组患者治疗前后血清谷胱甘肽过氧化物酶(GSH-PX)、超氧化物歧化酶(SOD)、肺功能:第1秒钟用力呼吸容积(FEV1)/用力肺活量(FVC)、第1秒用力呼气量占预计值百分比(FEV l%预计值),血气分析:动脉血二氧化碳分压(PaCO 2)、氧分压(PaO 2),以及临床症状评价。③结果雾化组及口服组患者治疗后2周的SOD、GSH-PX水平均较治疗前显著升高( P < 0.05 ),临床症状、FEVl%预计值、FEV1/FVC、PCO2、PO2 值结果较治疗前均好转( P < 0.05 ),雾化组与口服组组间对比上述指标均无显著性差异( P > 0.05 )。④结论NAC通过口服与雾化给药治疗AECOPD均有效果且效果无明显差异。
Objective To compare the clinical efficacy of different N-acetylcysteine administration measures in the treatment of patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).Methods A total of 64 patients with AECOPD who were admitted to the affiliated hospital of North China University of Technology from November 2017 to March 2018 were selected and randomly assigned to 32 patients in the aerosol group and 32 in the oral group.The enrolled patients were given an inhaled acetylcysteine solution for inhalation and acetylcysteine effervescent tablet soaked in water on the basis of comprehensive treatment such as anti-inflammatory and anti-asthma.Comparison of serum glutathione peroxidase(GSH-PX),superoxide dismutase(SOD),pulmonary function:FEV1/FVC,and forced expiratory volume in the first second before and after treatment in the nebulized and oral groups Percentage of values(FEV l% predicted),blood gas analysis:PaCO 2,PaO 2,and clinical symptom evaluation.Results After treatment,the SOD and GSH-PX levels in the nebulized group and the oral group were significantly higher than before treatment( P < 0.05 ).The patients in the nebulized group and the oral group were compared with clinical symptoms,FEVl% predicted value,FEV1/FVC,PCO 2 The results of PO 2 and PO 2 values were all better than those before treatment( P < 0.05 ).There was no significant difference between the aerosolized group and the oral group ( P > 0.05 ).Conclusion NAC treatment of AECOPD by both oral and atomized administration was effective and no significant difference was observed.
作者
张明洋
李新如
尹涵
喻昌利
ZHANG Mingyang;LI Xinru;YIN Han(Department of Respiratory Medicine,Affiliated Hospital of North China University of Technology,Tangshan063000,China)
出处
《华北理工大学学报（医学版）》
2019年第4期270-273,284,共5页
Journal of North China University of Science and Technology：Health Sciences Edition
