摘要
目的:通过光学相干断层扫描血管成像(OCTA)技术观察湿性年龄相关性黄斑变性(wARMD)经抗血管内皮生长因子(VEGF)治疗后的脉络膜新生血管(CNV)选定病灶面积(CSA)和血流面积(CFA)变化情况,探讨OCTA在该类疾病治疗效果评估方面的优势。方法:回顾性分析2018-02/2019-07在我院眼科确诊为wARMD并且在我院接受首次抗VEGF药物治疗及后续治疗的患者22例27眼纳入分析研究。所有患者均按3+prn方案给予抗VEGF药物治疗。对比观察患眼治疗前后最佳矫正视力(BCVA),黄斑中心凹视网膜厚度(CMT)、CSA、CFA变化。采用Pearson相关分析法,分析BCVA(LogMAR)与CMT、CSA、CFA的相关性。结果:wARMD患眼治疗后3mo BCVA(0.512±0.367)、CMT(223.271±17.795μm)、CSA(0.085±0.013mm2)、CFA(0.015±0.008mm2)较治疗前均显著改善(P<0.05);治疗后3mo BCVA与治疗前及治疗后3mo CMT、CSA、CFA均呈正相关(P<0.05)。结论:OCTA能够清晰显示并量化wARMD抗VEGF药物治疗前后CSA和CFA变化,为wARMD治疗效果评估提供参考。
·AIM:To observe the changes of selected area of choroidal neovascularization(CSA)and flow area of choroidal neovascularization(CFA)before and after the treatment of anti-vascular endothelial growth factor(VEGF)by optical coherence tomography angiography(OCTA),and to explore the advantages of OCTA in the treatment and prognosis of wet age-related macular degeneration(wAMD).·METHODS:A retrospective analysis was performed on 22 patients(27 eyes)who were diagnosed with wARMD and received the first anti-VEGF drug treatment and subsequent treatment in the Department of Ophthalmology of our hospital from 2018-02 to 2019-07.All patients were treated with anti-VEGF drugs according to the 3+prn regimen.The best corrected visual acuity(BCVA),macular foveal retinal thickness(CMT),CSA,and CFA were compared before and after treatment.We analyzed the correlation between BCVA(LogMAR)and CMT,CSA,CFA by Pearson correlation analysis.·RESULTS:After 3mo of the treatment,the mean LogMAR BCVA(0.512±0.367),CMT(223.271±17.795μm),CSA(0.085±0.113mm2)and CFA(0.015±0.008mm2)were significantly lower than those before treatment(P<0.05).The results of correlation analysis showed that the post-BCVA was positively correlated with pre-CMT,post-CMT,pre-CSA,post-CSA,pre-CFA and post-CFA(P<0.05).·CONCLUSION:OCTA can directly display and quantify the changes of CSA and CFA before and after anti-VEGF treatment of wAMD,and provide a reference for the evaluation of wAMD treatment effects.
作者
汪亮
吴文生
周丽
李燕
刘会德
Liang Wang;Wen-Sheng Wu;Li Zhou;Yan Li;Hui-De Liu(Department of Ophthalmology, Ophthalmic Hospital of Wuhu, Wuhu 241002, Anhui Province, China)
出处
《国际眼科杂志》
CAS
北大核心
2020年第6期1071-1074,共4页
International Eye Science
