摘要
目的:以光学相干断层扫描血管成像(optical coherence tomography angiography,OCTA)观察视网膜分支静脉阻塞(branch retinal vein occlusion,BRVO)抗血管内皮生长因子(vascular endothelial growth factor,VEGF)治疗前后的变化。方法:回顾性收集从2017年1月至2018年12月在汕头国际眼科中心的确诊为B RV O合并黄斑水肿的患者共31例32眼。患眼行玻璃体腔注射抗VEGF药物治疗,记录治疗前和治疗后1个月的最佳矫正视力(best corrected visual acuity,BCVA),OCTA检查视网膜黄斑中心凹厚度(foveal macular thickness,FMT)、黄斑区血流密度。比较治疗前后各指标的变化。结果:治疗后BCVA较治疗前显著提高,差异有统计学意义(P<0.001);FMT[(242.13±86.02)μm]较治疗前[(521.44±190.27)μm]明显下降,差异有统计学意义(P<0.001);中心凹浅层血流密度[(18.44±4.98)%]及中心凹旁浅层血流密度[(44.83±3.19)%]均较治疗前[(25.46±9.21)%,(46.06±5.25)%]相比明显下降,差异有统计学意义(P<0.001)。结论:玻璃体腔注射抗VEGF治疗BRVO合并黄斑水肿效果显著;OCTA能有效评价抗VEGF治疗B RVO合并黄斑水肿的临床疗效。
Objective:To evaluate the efficacy in patients with macular edema due to branch retinal vein occlusion(BRVO)treated with intravitreal anti-VEGF drug.Methods:In this retrospective study,32 eyes of 31 patients with BRVO combined with macular edema at Joint Shantou international eye center of Shantou University and The Chinese University of Hong Kong during January 2017 to December 2018 were enrolled in this study.All the affected eyes received intravitreal anti-VEGF drug injections.BCVA(best corrective visual acuity)and optical coherence tomography angiography(OCTA)were performed before and one month after intravitreal anti-VEGF drug injections.Foveal macular thickness(FMT),macular blood flow density was measured in all eyes and compared.Results:The BCVA before therapy was(0.77±0.46)LogMAR and increased to(0.46±0.30)LogMAR in one month after therapy,which showed a statistical difference(P<0.001).The FMT,foveal superficial vascular plexus flow density and para foveal superficial vascular plexus flow density before therapy were(521.44±190.27)μm,(21.85±6.17)% and(46.29±2.70)%,respectively.The FMT,foveal superficial vascular plexus flow density and para foveal superficial vascular plexus flow density decreased to(242.13±86.02)μm,(18.40±5.18)%and(44.75±3.40)%,respectively.There was significant statistical difference for them(P<0.001).Conclusion:Intravitreal injection of anti-VEGF is effective in the treatment of BRVO combined with macular edema.OCTA can effectively evaluate the clinical efficacy of anti-VEGF in the treatment of BRVO combined with macular edema.
作者
金创
夏红和
陆雪辉
陈浩宇
JIN Chuang;XIA Honghe;LU Xuehui;CHEN Haoyu(Shantou International Eye Center of Shantou University and Chinese University of Hong Kong,Shantou Guangdong 515041,China)
出处
《眼科学报》
2020年第1期28-32,共5页
Eye Science
基金
广东省医学科学技术研究基金(B2018142)。
关键词
光学相干断层扫描血管成像
视网膜分支静脉阻塞
黄斑水肿
抗血管内皮生长因子
optical coherence tomography angiography
branch retinal vein occlusion
macular edema
anti-vascular endothelial growth factor drug injections
