摘要
目的:探讨抗血管内皮生长因子(VEGF)药物治疗脉络膜新生血管(CNV)的疗效及对眼压、最佳矫正视力(BCVA)及多焦视网膜电图(mfERG)的影响。方法:选取2015-02/2017-01在我院治疗的特发性CNV患者44例44眼,均给予玻璃体腔注射抗VEGF药物治疗,观察患者治疗前后BCVA、眼压、mfERG及中央视网膜厚度(CRT)的变化情况。结果:治疗后1、3mo BCVA和CRT均较治疗前明显改善(P<0.05),其中治疗后3mo BCVA和CRT分别为0.60±0.15和278.43±40.10μm,明显较治疗后1mo改善(P<0.05)。治疗后1、3mo和治疗前眼压比较无明显变化(P>0.05)。治疗后1、3mo Ring1、Ring2和Ring4 NI-P1振幅密度均较治疗前提高(P<0.05);治疗后3mo,Ring3 NI-P1振幅密度均较治疗前和治疗后1mo提高(P<0.05);治疗后1mo,Ring5 NI-P1振幅密度较治疗前和治疗后3mo均提高(P<0.05);治疗后1、3mo和治疗前Ring6 NI-P1振幅密度比较无明显变化(P>0.05)。结论:抗VEGF药物治疗特发性CNV有较好的效果,能改善患者视力及黄斑区视网膜功能,降低视网膜厚度,且不影响眼压。
AIM： To investigate the efficacy of anti-vascular endothelial growth factor（VEGF）drugs in the treatment of choroidal neovascularization（CNV）and its effects on intraocular pressure, best corrected visual acuity（BCVA）and multifocal electroretinogram（mfERG）. METHODS：Totally 44 cases（44 eyes）of idiopathic CNV patients treated in our hospital from February 2015 to January 2017 were selected. All patients were treated with intravitreal injection of anti-VEGF. BCVA, intraocular pressure, mfERG and central retinal thickness（CRT）were observed after treatment.RESULTS： At 1 and 3mo after treatment, BCVA and CRT were significantly improved than those before treatment（P〈0.05）. At 3mo after treatment BCVA and CRT were 0.60±0.15 and 278.43±40.10μm, both significantly lower than that in 1mo after treatment（P〈0.05）. There was no significant change in intraocular pressure at 1 or 3mo after treatment than before treatment（P〉0.05）. At 1 and 3mo after treatment, amplitudes of Ring1, Ring2 and Ring4 NI-P1 were higher than those before treatment（P〈0.05）; at 3mo after treatment, the amplitude of Ring3 NI-P1 were higher than those before and 1mo after treatment（P〈0.05）; at 1mo after treatment, the amplitude of Ring5 NI-P1 were higher than those before and 3mo after treatment（P〈0.05）. The amplitude of Ring6 NI-P1 did not change significantly at 1 and 3mo after treatment, compared with before treatment（P〉0.05）. CONCLUSION： Anti-VEGF drugs are effective in the treatment of idiopathic CNV, which can improve vision and macular retinal function, decrease the retinal thickness, and do not affect the intraocular pressure.
出处
《国际眼科杂志》
CAS
北大核心
2018年第2期353-355,共3页
International Eye Science
关键词
血管内皮生长因子
脉络膜新生血管
最佳矫正视力
眼压
多焦视网膜电图
vascular endothelial growth factor
choroidal neovascularization
best corrected visual acuity
intraocular pressure
multifocal electroretinogram
