摘要
髓样分化因子88(MYD88)是细胞内传递信号的关键衔接蛋白,可介导多种Toll样受体(TLR)、白细胞介素1受体(IL-1R)及白细胞介素-18受体(IL-18R)的信号传递,在固有免疫中发挥显著作用。MYD88依赖通路在多种病原体致病过程中发挥作用,与肿瘤、感染性疾病、自身免疫性疾病等密切相关。MYD88依赖通路被认为是这些疾病治疗的关键靶点。MYD88基因L265P突变导致MYD88蛋白Toll-白细胞介素1受体域(TIR)的265位氨基酸发生改变。该突变可通过加强核因子-κB(NF-κB)等转录因子促进酪氨酸激酶-信号转导子和转录激活子3(JAK-STAT3)信号通路传导,介导白细胞介素(IL)-6、IL-10及β-干扰素(IFN-β)等炎症因子的产生。文章从MYD88的结构、基本功能、在信号传导通路中的作用以及MYD88基因L265P突变与疾病的关联等方面进行综述。
Myeloid differentiation factor 88(MYD88)is an important adaptor protein mediating the signal transduction of Toll-like receptors(TLR),interleukin 1 receptor(IL-1R)and interleukin 18 receptor(IL-18R),which plays a key role in innate immunity.MYD88-dependent pathways play roles in the pathogenesis of multiple pathogens and have relations with tumors,infectious diseases,autoimmune diseases and so on,which are considered to be important targets for the intervention of these diseases.The L265P mutant in MYD88,an amino acid change(L265P)in the MYD88 Toll-like receptor/interleukin 1 receptor(TIR),promotes Janus kinase-signal transducer and activator of transcription 3(JAK-STAT3)signaling pathway by enhancing transcription factors such as nuclear factor kappa B(NF-κB),and mediates the production of inflammatory factors such as interleukin(IL)-6,IL-10 and interferon-beta(IFN-β).The structure and fundamental function of MYD88 and its role in signal transduction are reviewed.Furthermore,the association between MYD88 L265P and diseases are also illustrated.
作者
胡玉懿
陈朴(综述)
郭玮
潘柏申(审校)
HU Yuyi;CHEN Pu;GUO Wei;PAN Baishen(Department of Clinical Laboratory,Zhongshan Hospital,Fudan University,Shanghai 200032,China)
出处
《检验医学》
CAS
2020年第4期380-386,共7页
Laboratory Medicine
基金
国家自然科学基金资助项目(81572064)
国家自然科学基金资助项目(81772263)
上海市卫生计生系统重要薄弱学科建设项目(2015ZB0201)。
