摘要
目的:探讨早期预防性应用枸橼酸咖啡因对早产儿支气管肺发育不良(BPD)的防治作用及炎症因子的影响。方法:选择2019年1月-2022年2月江西省儿童医院收治的80例早产儿为观察对象,按照治疗方法的不同分为对照组(25例,予以常规治疗)、治疗A组(28例,于出生72 h内即开始给予枸橼酸钠咖啡因治疗)与治疗B组(27例,于出生72 h后给予枸橼酸钠咖啡因治疗)。比较三组BPD发生率和呼吸支持情况;观察三组患儿并发症的发生率及用药前后炎症指标[白细胞介素-6(IL-6)和白细胞介素-8(IL-8)及肿瘤坏死因子-α(TNF-α)]水平变化。结果:治疗B组与对照组BPD的发生率差异无统计学意义(P>0.05),治疗A组BPD发生率与治疗B组差异无统计学意义(P>0.05),但治疗A组BPD发生率低于对照组(P<0.05),治疗A组BPD分度情况优于对照组(P<0.05);治疗A组和治疗B组机械通气时间、持续气道正压通气治疗(CPAP)时间和总需氧时间均短于对照组(P<0.05),治疗A组机械通气时间、CPAP时间和总需氧时间均少于治疗B组(P<0.05);治疗A组和治疗B组并发症发生率均低于对照组,但差异均无统计学意义(P>0.05);治疗第5天,治疗A组和治疗B组IL-6、IL-8和TNF-α均低于对照组,且治疗A组上述炎症指标均低于治疗B组,差异均有统计学意义(P<0.05)。结论:于早产儿出生后72 h内预防性应用枸橼酸咖啡因可有效防治早产儿BPD,利于改善其呼吸支持系统,降低炎症指标水平。
Objective:To explore the preventive and therapeutic effects of early prophylactic application of Caffeine Citrate on bronchopulmonary dysplasia(BPD)in premature infants and its influence on inflammatory factors.Method:A total of 80 premature infants admitted to Jiangxi Provincial Children’s Hospital from January 2019 to February 2022 were selected as observation subjects,and they were divided into control group(25 cases,given routine treatment),treatment group A(28 cases,treated with Caffeine Citrate within 72 hours of birth)and treatment group B(27 cases,given Caffeine Citrate at 72 hours after birth)according to different treatment methods.The incidence rate of BPD and respiratory support among the three groups were compared,and the changes in incidence rates of complications and inflammatory indicators of interleukin-6(IL-6),interleukin-8(IL-8)and tumor necrosis factor-α(TNF-α)before and after medication in the three groups were observed.Result:There was no significant difference in the incidence rate of BPD between treatment group B and control group(P>0.05),and there was also no significant difference in the incidence rate of BPD in treatment group A compared to treatment group B(P>0.05),but the incidence rate of BPD in treatment group A was lower than that in control group(P<0.05),and the BPD degrees in treatment group A was better than that in control group(P<0.05).The mechanical ventilation time,continuous positive airway pressure(CPAP)time and total oxygen demand time in treatment group A and treatment group B were shorter than those in the control group(P<0.05),and the mechanical ventilation time,CPAP time and total aerobic time in treatment group A were lower than those in treatment group B(P<0.05).The incidence of complications in treatment group A and treatment group B were lower than that in the control group,but the differences were not statistically significant(P>0.05).On the fifth day of treatment,the levels of IL-6,IL-8and TNF-αin treatment group A and treatment group B were lower than thos
作者
刘春子
何帆
LIU Chunzi;HE Fan(Jiangxi Provincial Children's Hospital,Nanchang 330003,China;不详)
出处
《中国医学创新》
CAS
2023年第5期18-22,共5页
Medical Innovation of China
基金
江西省卫生健康委科技计划项目(SKJP520200404)。
关键词
早产儿
枸橼酸咖啡因
支气管肺发育不良
机械通气
炎症指标
Premature infant
Caffeine Citrate
Bronchopulmonary dysplasia
Mechanical ventilation
Inflammatory indicators
