摘要
谵妄是一种急性脑功能障碍,可导致住院时间及住ICU时间延长,并是导致长期认知障碍的独立危险因素,给患者及其家属、医院和公共资源带来巨大负担。近年来,对谵妄的研究越来越成为医学研究的热点,目前对于谵妄的研究主要集中在谵妄发生的危险因素、药物干预、非药物干预等方面,对于其病理生理机制尚未有一个完整理论可以充分解释,但是大量的研究表明中枢神经炎性在谵妄的发生发展中至关重要,现有一些研究提示TOLL样受体通过介导中枢炎性反应从而影响神经递质传递、神经元凋亡等过程,进而导致谵妄的发生。这种基于分子基础的研究,可能为探索谵妄的病理生理机制及防治提供新思路。
Delirium is an acute brain dysfunction leading to prolonged hospitalization and stay in the ICU.It is also an independent risk factor for long-term cognitive impairment,which brings a huge burden on patients and their families,hospitals and public resources.In recent years,the study of delirium has become a hot spot in medical research.At present,the research on delirium mainly focuses on the risk factors of delirium,drug intervention,non-drug intervention,etc.A thorough theory to comprehensively reveal the pathophysiological mechanism of delirium is lacked,but a large number of studies have shown that the inflammation in the central nervous system(CNS)is crucial in the occurrence and development of delirium.Toll-like receptors affect neurotransmitter transmission,neuronal apoptosis and other processes through mediating the inflammatory response in the CNS,thus leading to delirium.This study is based on molecular findings,which may provide new ideas for exploring the pathophysiological mechanism and prevention and treatment of delirium.
作者
陈莉
史惠文
袁媛
CHEN Li;SHI Huiwen;YUAN Yuan(First School of Clinical Medical,Gansu University of Chinese Medicine,Gansu,Lanzhou 730000,China;不详)
出处
《河北医药》
CAS
2023年第14期2202-2206,共5页
Hebei Medical Journal
基金
甘肃省自然科学基金(编号:21JR1RA038)。
关键词
谵妄
TOLL样受体
中枢神经炎症反应
信号转导途径
delirium
toll-like receptor
inflammatory response in the central nervous system
signal transduction pathway
