摘要
溃疡性结肠炎(UC)目前病因尚不十分清楚,病程漫长,反复发作。情志因素在溃疡性结肠炎的发生、发展过程中起着重要作用,建立正确合理的肝郁脾虚型溃疡性结肠炎动物模型对研究溃疡性结肠炎具有非常重要的意义。文章总结了近年来中医传统病因法、西医病因病理法、中西医病证结合法等建立肝郁脾虚型溃疡性结肠炎大鼠模型的原理、方法(包括具体剂量范围、时间)及其优缺点,探讨了当前存在的问题,以期为建造最正确合理的肝郁脾虚型溃疡性结肠炎提供可能。
Ulcerative colitis(UC)is one of the modern refractory disease without clear causes,the disease has the feature of long course and recurrent episodes.Emotional factors play an important role in the occurrence and development of UC,so it is of great significance to establish an appropriate animal model of UC with Liver depression and Spleen deficiency.The article summarized the principle,the method,as well as the advantages and disadvantages of UC models established based on TCM etiology,etiology and pathology of western medicine,and combined syndrome of traditional Chinese and western medicine,aiming to find the most reasonable UC model of Liver depression and Spleen deficiency.
作者
柳荣
申睿
朱向东
高艳奎
王欢
钟兴腾
LIU Rong;SHEN Rui;ZHU Xiangdong;GAO Yankui;WANG Huan;ZHONG Xingteng(Gansu University of Chinese Medicine, Lanzhou 730000, China)
出处
《中医药学报》
CAS
2020年第4期76-80,共5页
Acta Chinese Medicine and Pharmacology
基金
国家自然科学基金项目(81760833)。
关键词
溃疡性结肠炎
肝郁脾虚
实验模型
束缚
Ulcerative colitis
Liver depression and Spleen deficiency
Experimental model
Constraint
