摘要
目的分析2016~2019年天津市河北区健康人群手足口病毒抗体及感染免疫情况,为手足口病防控提供依据。方法收集2016~2019年天津市河北区某医院作为监测医院进行健康体检的静脉血标本171例,均进行EV71、Cox A16、Cox A6中和抗体测定,分析手足口病中和抗体阳性分布情况及不同年龄段抗体滴度构成情况。结果共171例血标本中EV71、Cox A16、Cox A6中和抗体阳性率分别为64.91%(111/171)、62.57%(107/171)、62.57%(107/171),三者阳性率比较,差异无统计学意义(?字2=0.082,P=0.960)。不同性别EV71、Cox A16、Cox A6中和抗体阳性率比较,差异有统计学意义(P<0.05);不同年龄组EV71、Cox A16中和抗体阳性率比较,差异有统计学意义(P<0.05);不同年龄组Cox A6中和抗体阳性率比较,差异无统计学意义(P>0.05)。EV71中和抗体滴度最高的为<1∶4,占比20.47%(35/171);Cox A16、Cox A6中和抗体滴度最高的为1∶16,占比23.39%(40/171)、30.99%(50/171)。各年龄段EV71、Cox A16、Cox A6中和抗体几何平均滴度分别为34.09、17.68、17.77,其中EV71、Cox A16中和抗体几何平均滴度均以0~5岁年龄最低,Cox A6中和抗体几何平均滴度却以0~5岁年龄段最高。结论EV71、Cox A16、Cox A6手足口病毒的感染人群比例较大,Cox A6抗体水平分布与EV71、Cox A16存在差异,其中EV71、Cox A16抗体阳性率以5岁以下年龄段人群最低,应进行重点防控。
Objective To analyze the HFMD antibody and immunization status of healthy people in Hebei District of Tianjin from 2016 to 2019 to provide a basis for the prevention and control of HFMD.Methods Collected 171 cases of venous blood samples from a hospital in Hebei District,Tianjin City as a monitoring hospital from 2016 to 2019,all neutralizing antibodies were tested for EV71,Cox A16,Cox A6,the positive distribution of neutralizing antibodies and the composition of antibody titers of different ages were analyzed.Results A total of 171 blood samples had positive rates of EV71,Cox A16,and Cox A6 neutralizing antibodies of 64.91%(111/171),62.57%(107/171),and 62.57%(107/171).The positive rates of the three were compared.The difference was not statistically significant(?字2=0.082,P=0.960).The positive rate of neutralizing antibodies of EV71,Cox A16,Cox A6 of different genders was statistically significant(P<0.05);the positive rate of neutralizing antibodies of EV71,Cox A16 of different age groups was statistically significant(P<0.05);The positive rate of Cox A6 neutralizing antibody in different age groups was not statistically significant(P>0.05).The highest titer of neutralizing antibody of EV71 was<1:4,accounting for 20.47%(35/171);the highest titer of neutralizing antibody of Cox A16 and Cox A6 was 1:16,accounting for 23.39%(40/171),30.99%(50/171).The geometric mean titers of EV71,Cox A16 and Cox A6 neutralizing antibodies of various ages were 34.09,17.68 and 17.77 respectively.Among them,the geometric mean titers of EV71,Cox A16 neutralizing antibodies were the lowest from 0 to 5 years old,and Cox A6 the antibody geometric mean titer is the highest in the age group of 0~5 years old.Conclusion The proportion of infected people with EV71、Cox A16、Cox A6 hand,foot and mouth virus is large,and the level distribution of Cox A6 antibody is different from that of EV71、Cox A16,among which the positive rate of antibody is the lowest in the population under 5 years old,so the key prevention and control should be carrie
作者
宋丹
SONG Dan(Tianjin Hebei District Center for Disease Control and Prevention,Tianjin 300150,China)
出处
《医学信息》
2020年第8期147-149,共3页
Journal of Medical Information
