摘要
目的调查天津市河东区健康人群肠道病毒71型（EV71）和科萨奇病毒A组16型（CoxA16）隐性感染状况,为手足口病的预防与控制提供依据。方法采集148名天津市河东区健康人静脉血标本进行EV71和CoxA16中和抗体测定,对检测结果进行分析。结果以抗体滴度1∶4作为临界值,调查对象EV71中和抗体阳性率为79.05%（117/148）,CoxA16中和抗体阳性率为80.41%（119/148）;其中,EV71中和抗体阳性率和CoxA16中和抗体阳性率最高的年龄组均为36-45岁,分别为93.10%和96.55%;0-5岁年龄组的EV71中和抗体阳性率和CoxA16中和抗体阳性率最低,分别为50.00%和46.15%。不同年龄组的EV71中和抗体阳性率和CoxA16中和抗体阳性率差异均有统计学意义（均P〈0.01）。EV71和CoxA16中和抗体滴度≥1∶256的人数分别占20.95%（31/148）和16.22%（24/148）。结论人群对EV71和CoxA16普遍容易感染,健康人群中存在较高的隐性感染,因此隐性感染人群也是病原体传播的传染源之一。
[ Objective] To investigate the latent infection caused by enterovirus 71 （EV71） and coxasckievirus A16 （CoxA16） among healthy people in Hedong District of Tianjin, provide evidence for prevention and control of hand-foot-mouth disease （ HFMD）. [ Methods ] The venous blood samples were collected from 148 healthy people in Hedong District of Tianjin, to detect the neutralizing antibody of EV71 and CoxA16, and the results were analyzed statistically. [ Results ] According to the critical value for the antibody titer of 1 ： 4, the positive rate of neutralizing antibody against EV71 and CoxA16 was 79.05% （ 117/148 ） and 80. 41% （119/148） respectively. Both the positive rates of neutralizing antibody against EV71 and CoxA16 were the highest in 36- 45 year-old age group, which was 93.10% and 96.55% respectively. The positive rates of neutralizing antibody against EV71 and CoxA16 were the lowest in 0-5 year-old age group, which was 50.00% and 46.15% respectively. There were significant differences in the positive rates of neutralizing antibody against EV71 and CoxA16 among different age groups （all P 〈 0.01）. The people whose titer of neutralizing antibody against EV71 and CoxA16 was equal or greater than 1 ： 256 accounted for 20.95% （31/148） and 16.22% （24/148 } respectively. [ Conclusion] People are generally susceptible to EV71 and CoxA16, and the latent infection with HFMD has maintained a high level in healthy population. The latent infection population plays a very important role in transmission of HFMD.
出处
《职业与健康》
CAS
2014年第19期2753-2755,共3页
Occupation and Health
关键词
手足口病
隐性感染
血清流行病学
Hand-foot-mouth disease （HFMD）
Latent infection
Seroepidemiology
