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中医药疗法调节miRNA对心肌缺血再灌注损伤影响的研究进展 被引量:8

Research progress of regulation of miRNA on myocardial ischemia reperfusion injury by traditional Chinese medicine
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摘要 综述中医药通过调节微小核糖核酸(miRNA)对心肌缺血再灌注损伤影响的研究进展。相关研究结果表明,中药单体(人参皂苷1、芹菜素、丹酚酸B、木犀草素等)、复方(如益气活血复方、通心络)及针灸(如电针预处理、电针内关穴、体内双内关穴电针和体外微电流预处理)可通过调控miRNA治疗心肌缺血再灌注损伤,为中医药治疗心肌缺血再灌注损伤及其相关预后干预提供切入点。 This paper reviews the latest research progress in the treatment of myocardial ischemia reperfusion injury(MIRI)by regulating micro ribonucleic acid(miRNA)as a target with traditional Chinese medicine monomer(ginsenoside 1,apigenin,salvianolic acid B,luteolin),compound prescription(Yiqi Huoxue compound,Tongxinluo)and acupuncture[electroacupuncture pretreatment,needling neiguan(PC6)point by electroacupuncture,needling neiguan(PC6)point in both sides by electroacupuncture in vivo and microcurrent pretreatment in vitro],which provides an entry point for traditional Chinese medicine treatment of myocardial ischemia reperfusion injury and related prognosis intervention.
作者 李冀 李想 胡晓阳 潘明月 曹明明 LI Ji;LI Xiang;HU Xiaoyang;PAN Mingyue;CAO Mingming(School of Basic Medicine,Heillongjiang University of Traditional Chinese Medicine,Harbin 150040,Heillongjiang,China)
出处 《上海中医药杂志》 2020年第3期97-100,共4页 Shanghai Journal of Traditional Chinese Medicine
基金 国家中医药管理局名老中医工作室项目 国家自然科学基金资助项目(20012130004) 黑龙江省博士后基金项目(LBH-Z16189) 黑龙江中医药大学校科研基金资助项目(2015BS02) 黑龙江省普通本科高等学校青年创新人才培养计划项目(UPYSCT-2018226)。
关键词 心肌缺血再灌注损伤 MIRNA 中医药疗法 综述 myocardial ischemia reperfusion injury miRNA traditional Chinese medicine therapy review
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