摘要
目的系统评价细胞微核与多囊卵巢综合征(PCOS)的相关性。方法计算机检索PubMed、OVID、Elsevier、CNKI、WanFang Data和CBM数据库,搜集有关细胞微核与PCOS相关性的病例-对照研究,检索时限均从建库至2019年4月。由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用RevMan 5.3软件进行Meta分析。结果共纳入5个病例-对照研究,包括PCOS组170例,对照组148例。Meta分析结果显示,PCOS组外周血淋巴细胞的微核率[MD=2.02%,95%CI(1.63%,2.41%),P<0.000 01]和口腔黏膜上皮细胞的微核细胞率[MD=2.43%,95%CI(0.10%,4.76%),P=0.04]均高于对照组。结论当前证据表明,细胞微核率升高与PCOS有一定相关性。受纳入研究数量和质量的限制,上述结论尚待更多高质量研究予以验证。
Objectives To systematically review the association of micronucleus and polycystic ovary syndrome(PCOS).Methods PubMed,OVID,Elsevier,CNKI,WanFang Data and CBM databases were electronically searched to collect case-control studies on the association of micronucleus and PCOS.Two reviewers independently screened literature,extracted data and assessed risk of bias of included studies.Meta-analysis was then performed using RevMan 5.3 software.Results A total of 5 case-control studies were included,in which 170 patients were in the case group and 148 in the control group.The results of meta-analysis showed:there were significant differences between two groups for micronucleus frequency(MD=2.02%,95%CI 1.63%to 2.41%,P<0.00001)in peripheral blood lymphocytes and micro nucleated cells frequency(MD=2.43%,95%CI 0.10%to 4.76%,P=0.04)in oral epithelial cells.Conclusions The current evidence shows that micronucleus is associated with PCOS.Due to limited quality and quantity of the included studies,more high quality studies are required to verify above conclusion.
作者
李晓珍
宋泽丽
王业丰
曹文婷
黄海溶
LI Xiaozhen;SONG Zeli;WANG Yefeng;CAO Wenting;HUANG Hairong(Department of Epidemiology,School of Public Health,Hainan Medical University,Haikou,571199,P.R.China;Department of Toxicology,College of Public Health,China Medical University,Shenyang,110001,P.R.China;School of Public Health and Management,NingXia Medical University,Yinchuan,750004,P.R.China)
出处
《中国循证医学杂志》
CSCD
北大核心
2020年第2期181-185,共5页
Chinese Journal of Evidence-based Medicine
基金
海南医学院科研培育基金项目(编号:HY2018-14)
海南省大学生创新创业训练计划项目专项资金项目(编号:2017111)
