摘要
目的定量评价胆固醇侧链裂解酶基因（CYPlla）启动子（tttta）4、（tttta）6和（tttta）8微卫星多态性与多囊卵巢综合征（PCOS）发生的关联性及关联强度。方法制定原始文献的纳入和排除标准及检索策略。检索中外数据库，系统收集有关CYPlla多态性与PCOS相关性的研究报告，按照NOS标准对纳入文献进行质量评价。应用RevMan5．0软件对各文献进行异质性检验和Meta分析，得出合并后的OR值及其95％CI。结果共有8篇文献纳入Meta分析。数据合并结果显示，CYPlla启动子（tttta）。微卫星多态性与PCOS易感性之间关联性有统计学意义，OR值（95％C1）为O．75（0．59—0．95）；（tttta）。和（tttta）。微卫星多态性与PCOS易感性之间关联性无统计学意义，OR值（95％C1）分别为0．89（0．61～1．30）和0．84（0．64～1．11）。结论CYP11a启动子（tttta）。微卫星多态性是PCOS发病的保护因素，尚未见（tttta）4和（tttta）。微卫星多态性与PCOS发病风险之间的关联性。
Objective To explore the association between microsatellite polymorphism （tttta） 4, （tttta） 6 and （tttta） 8 of gene CYP11 a and polycystic ovary syndrome （PCOS）. Methods Electronic search strategy was carded out among the 6 databases from home and abroad to collect qualified research papers according to the inclusion and exclusion criteria. Case-control studies on association between microsatellite polymorphism （tttta）n of gene CYP11 a and susceptibility to PCOS were collected. The combined OR values and their 95 % CI were calculated with Review Manager 5.0. Results A total of 8 eligible studies were included. Statistics of the combined data showed a significant difference between patients with PCOS carrying microsatellite polymorphism （tttta） 6 of gene CYP11 a and controls. The combined OR （95 % CI） was 0.75 （0.59-0.95）. There was no significant difference between patients with PCOS carrying microsatel- lite polymorphism （tttta）4 or （tttta）8 of gene CYPlla and controls. The combined OR（95% CI） were 0.89 （0.61- 1.30） and 0.84 （0.64-1.11 ） respectively. Conclusion The results suggest that microsatellite polymorphism （tttta） n of gene CYP11 a may not be a risk factor for PCOS, and （tttta）6 is a protective factor for PCOS.
出处
《山东大学学报（医学版）》
CAS
北大核心
2013年第10期85-89,共5页
Journal of Shandong University:Health Sciences
关键词
多囊卵巢综合征
胆固醇侧链裂解酶基因
多态性
META分析
Polycystic ovary syndrome
Cholesterol side chain cleavage enzyme gene
Polymorphism
Meta-analysis
