摘要
目的分析职业性铬暴露的工人尿铬水平与血清素、五羟基吲哚乙酸、褪黑素水平的相关性。方法选取市郊某电镀铬企业85名电镀工人作为暴露组,选取不接触铬生产线的工人120人为对照组,采集电感耦合等离子体质谱仪测定尿中铬水平,超高液相色谱串联质谱测定尿中血清素、五羟基吲哚乙酸、褪黑素水平,分析各组间指标的差异及尿铬水平与其的相关性。结果暴露组的尿铬水平(0.32±0.18)[log(μg/g肌酐)]高于对照组(0.23±0.11)[log(μg/g肌酐)],暴露组尿液中血清素和褪黑素水平高于对照组(P值均<0.05)。对照组、低暴露组、中暴露组、高暴露组之间血清素和褪黑素水平差异具有统计学意义(P值均<0.05),五羟基吲哚乙酸的差异无统计学意义(P>0.05)。尿铬水平与尿液中血清素、褪黑素水平呈正相关关系(β=0.152,95%CI:0.036~0.926;β=0.229,95%CI:0.269~1.065)。结论尿铬水平与尿液中血清素和褪黑素水平的增高呈正相关关系,未观察到与五羟基吲哚乙酸有关。
Objective To investigate the correlation of urine chromium level with serotonin,pentahydroxyindoleacetic acid and melatonin levels in workers with occupational chromium exposure.Methods A total of 85 chromium electroplating workers and 120 workers with no contact with electroplating production line in a electroplating factory were chosen as exposure group and control group,respectively;The urine samples were analyzed for chromium levels by inductively-coupled plasma mass spectrometry;serotonin,pentahydroxyindoleacetic acid and melatonin levels were measured by ultra-performance liquid chromatograph tandem mass spectrometry.The differences between the groups and influencing factors of urine chromium level were analyzed.Results The urine chromium level in exposure group(0.32±0.18)[log(μg/g creatinine)]was higher than that of the control group(0.23±0.11)[Iog(pig/g creatinine)].The urine levels of serotonin and melatonin in exposure group were higher than those in control group(all P<0.05).There were significant differences in pentahydroxyindoleacetic and melatonin levels among control group and low,middle,high level-exposure groups;while the urine pentahydroxyindoleacetic levels among groups showed no statistical difference(P>0.05).There was a positive correlation between urinary chromium and serum or melatonin(β=0.152,95%CI:0.036-0.926;β=0.229,95%CI:0.269-1.065).Conclusion There is a positive correlation between urinary chromium level and the increase of serotonin and melatonin level in urine while no significant correlation with betpentahydroxyindoleacetic acid is confirmed.
作者
吴林林
吴钢
王军
高蓉
刘文卫
WU Lin-lin;WU Gang;WANG Jun;GAO Rong;LIU Wen-wei(Wujci Municipal Center for Disease Control and Prevention,Jiangsu Wiuci 214023,China)
出处
《江苏预防医学》
CAS
2019年第6期608-610,共3页
Jiangsu Journal of Preventive Medicine
基金
无锡市“科教强卫工程”项目[CXPT(SYS)002]
关键词
职业性铬内暴露
血清素
五羟基吲哚乙酸
褪黑素
相关性
Occupational chromium exposure
Serotonin
Pentahydroxyindoleacetic acid
Melatonin
Correlation
