摘要
重症肌无力(MG)是一类以自身抗体所介导、发生在神经-肌肉接头处、以部分或全部骨骼肌波动性无力为表现的自身免疫性疾病。MG患者大多数合并胸腺异常,包括胸腺增生和胸腺瘤。目前认为异常胸腺是MG患者自身抗体产生的重要场所,切除异常胸腺是治疗MG的有效手段,甚至有报道切除正常的胸腺,也会改善MG患者肌无力症状。然而,关于胸腺切除术后MG复发的报道越来越多,原因尚不明确。目前研究发现患者发病年龄、病程、美国MG基金会(MGFA)分型、胸腺病理类型、Masaoka分级、是否合并其他自身免疫性疾病等因素均可能影响胸腺切除术后MG复发或疗效不佳。
Myasthenia gravis(MG), which clinical manifestations are partial or total skeletal muscle weakness fluctuantly, is an autoimmune disease mediated by autoantibodies attacking against neuromuscular junction. The great majority of MG patients have thymus abnormality including thymic hyperplasia or thymoma. It is universally known that the thymus is considered as the origin of autoantibody production in MG patients. Thus, thymectomy has became a suggested method for MG management. And it’s unexpectedly reported that excision of normal thymus can improve myasthenia symptoms in MG patients. However, increasingly cases that MG patients undergoing thymectomy have a relapse of myasthenia symptoms were reported and it’s mechanism remained a mystery. The extant study revealed that the age of onset, duration of disease, MGFA classification, Thymus pathology, Masaoka classification, combined with other autoimmune diseases may influence the recurrence or ineffectiveness in MG patients after thymectomy.
作者
汤旎
谷有全
张晓燕
尹榕
TANG Ni;GU You-quan;ZHANG Xiao-yan(Department of Neurology,the First Hospital of Lanzhou University,Lanzhou 730000,China)
出处
《临床神经病学杂志》
CAS
2019年第6期470-473,共4页
Journal of Clinical Neurology
