摘要
目的研究老年期重症肌无力（ＭＧ）的临床特点。方法将２０年间诊治的１９２４例ＭＧ，根据发病年龄分为小儿期ＭＧ（≤１４岁）、成年期ＭＧ（１５～５９岁）及老年期ＭＧ（≥６０岁）。采用χ２检验比较３组的临床资料。结果老年期ＭＧ在整个ＭＧ中构成比小（只占５．５％），男性发病者较多见（男∶女＝１．４∶１），以延髓症状首发者多见，合并胸腺瘤者多而合并其他自体免疫病者少，以延髓症状首发而误诊为脑血管病者多见，病死率高，但死于肌无力危象者少。结论老年期ＭＧ与成年期、小儿期相比有其独特之处，及时掌握其特点将有助于指导临床的诊断和治疗。
Objective To study the clinical characteristics of myasthenia gravis (MG) in the elderly patients. Methods The patients with MG were divided into three groups based on the onset of disease, which were juvenile MG (≤14 years), adult MG (15 ～ 59 years) and senile MG (≥60 years). The χ 2 test was employed to evaluate the difference of clinical manifestations between above groups. Results (1) There were more male patients than female ones in the senile MG group. (2) The bulbar muscular involvement as the first symptom was more frequently mistakenly diagnosed as a cerebrovascular disease in the senile MG group than in the other groups. (3) MG was seen to be associated in more patients with thymoma, but less with the other autoimmune diseases. (4) The mortality rate was higher in the senile MG group, but less patients with senile MG died of myasthenia crisis. Conclusion The senile MG had its own clinical characteristics. With the important information of the clinical manifestation available, it may facilitate the diagnosis and therapy in the elderly patients with MG.
出处
《中华神经科杂志》
CAS
CSCD
1998年第2期83-85,共3页
Chinese Journal of Neurology
