摘要
卵巢早衰是妇科常见病及疑难病,其发病率逐渐升高且呈年轻化趋势。作为女性的第二性器官,卵巢功能的过早衰竭严重危害全球女性的身心健康,是学者们研究与关注的焦点。目前认为卵巢早衰的发病原因是多方面的,其发病机理十分复杂,且尚未明确。就目前最新的研究发现与遗传因素、免疫因素、感染因素、医源性因素、代谢因素、精神心理因素、环境因素等因素有关。发病机制涉及基因突变,自身免疫性疾病,颗粒细胞及线粒体的异常等。该文对卵巢早衰的发病机制研究进展做一综述,为该病的预防及进一步研究提供参考。
Premature ovarian failure is a common gynecological and difficult disease. Its incidence rate is gradually rising and showing younger trend. As the second sexual organ of women,premature ovarian failure seriously endangers the physical and mental health of women all over the world. So it is the focus of scholars. At present,it is believed that the causes of premature ovarian failure is multifaceted. The pathogenesis is complex and unclear. The latest research finds that it related to genetic factors,immune factors,infectious factors,iatrogenic factors,metabolic factors,psychological factors,environmental factors and other factors. The pathogenesis involves gene mutation,autoimmune diseases,granulosa cell and mitochondrial abnormalities,etc. In this paper,it will give an overview about the progress in pathogenesis of premature ovarian failure and provides reference for the prevention and further study of the disease.
作者
郗红燕
张杨
赵小萱
冯晓玲
XI Hongyan;ZHANG Yang;ZHAO Xiaoxuan;FENG Xiaoling(Heilongjiang University of Chinese Medicine,Harbin 150040,Heilongjiang,China;The First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150040,Heilongjiang,China)
出处
《辽宁中医药大学学报》
CAS
2019年第12期103-106,共4页
Journal of Liaoning University of Traditional Chinese Medicine
基金
国家自然科学基金项目（81373673）
关键词
卵巢早衰
基因突变
自身免疫性疾病
线粒体
颗粒细胞
发病机制
premature ovarian failure
gene mutation
autoimmune diseases
mitochondria
granulosa cells
pathogenesis
