摘要
近年来,卵巢早衰(POF)的发病率呈现逐年上升的趋势,严重影响育龄期妇女的生活和对生育的要求。但POF病因复杂,主要发病因素有医源性因素、环境因素、遗传因素、感染因素及免疫性因素等。有大量研究报道自身免疫性疾病患者并发POF的病例。有研究报道转化生长因子β1(TGF-β1)在POF和类风湿关节炎患者血清中均表达降低,而炎症因子白细胞介素21(IL-21)、IL-6、IL-17则均表达升高,这些细胞因子及炎症因子均参与卵巢卵泡的发育闭锁过程。自身免疫性POF以自身免疫性抗体的发现及合并自身免疫性疾病为诊断要点。POF与自身免疫性疾病之间存在相同的表达因子,其免疫机制与自身免疫性疾病的免疫机制是否存在同源性有待进一步研究。
In recent years, the incidence of premature ovarian failure（POF） has been increasing year by year. It is well known that POF affects the life quality and fertility of those women of childbearing age. However,the causes of POF are complex, and the main factors are classified as iatrogenic factors, environmental factors,genetic factors, infectious factors, and immune factors, etc. A large number of POF cases were reported in patients with autoimmune diseases. The level of serum transforming growth factor β1（TGF-β1） was decreased in patients with POF orrheumatoid arthritis, while the levels of inflammatory factors interleukin 21（IL-21）, IL-6 and IL-17 were increased. It was reported that those cytokines and inflammatory factors were involved in the follicular development and atresia. The diagnosis of autoimmune-related POF is based on the discovery of autoimmune antibodies and the combined autoimmune diseases. Interestingly, there is high similarity in the expression profile of those factors between POF and autoimmune diseases. Whether autoimmune-related POF has a common mechanism with autoimmune diseases needs more study.
作者
曾富玲
孙维峰
ZENG Fu-ling;SUN Wei-feng(Department of Chinese Medicine,Guangzhou General Hospital of Guangzhou Military Command,Guangzhou 510010,China;Guangzhou University of Chinese Medicine,Guangzhou 510405,Chin)
出处
《国际生殖健康／计划生育杂志》
CAS
2018年第4期316-319,共4页
Journal of International Reproductive Health/Family Planning
