摘要
卵母细胞分泌的细胞因子在卵泡发育过程中起重要作用,如生长分化因子-9(GDF-9)可调控卵泡的早期发育和颗粒细胞凋亡。补肾法能有效调节卵巢早衰患者GDF-9蛋白表达、促进卵泡正常发育、抑制卵泡异常闭锁,从而改善卵巢功能。本文对补肾法通过调节GDF-9治疗卵巢早衰的研究进展做一综述,为该病防治提供参考。
Cytokines secreted by oocytes play an important role during the course of follicular development. For example, the growth differentiation factor-9（GDF-9） can regulate the early development of follicles and granulosa cells apoptosis. Bushen Therapy can effectively regulate the expression of GDF-9 protein in patients with premature ovarian failure（POF）, promote follicular development, and inhibit abnormal follicular atresia, thereby improving ovarian functions. This article reviewed the research progress in the treatment of POF with Bushen Therapy by regulating GDF-9 expression, which could provide references for the prevention and treatment of POF.
作者
王姝婉
梁嘉丽
杨静
秦佳佳
WANG Shu-wan;LIANG Jia-li;YANG Jing;QIN Jia-jia(TCM Department,Faculty of Medical Science,Jinan University,Guangzhou 510632,China)
出处
《中国中医药信息杂志》
CAS
CSCD
2018年第10期133-136,共4页
Chinese Journal of Information on Traditional Chinese Medicine
基金
国家自然科学基金面上项目(81373805)
广东省社会发展领域科技计划(2013B0216i00001)
关键词
卵巢早衰
生长分化因子-9
补肾法
综述
premature ovarian failure
growth differentiation factor-9
Bushen Therapy
review
