摘要
烟酰胺腺嘌呤二核苷酸磷酸氧化酶是心血管系统中活性氧(reactive oxygen species,ROS)的主要来源,它包括7种亚型并分别表达在不同的心血管细胞及其细胞器中,参与调节细胞增殖、迁移、分化、凋亡、衰老和炎症反应等多种活动,其衍生的ROS参与高血压、动脉粥样硬化、糖尿病血管病变、心肌梗死后心室重构等多种心血管疾病的病理过程。
Nicotinamide adenine dinucleotide phosphate oxidase(NOX)is a major source of reactive oxygen species(ROS)in the cardiovascular system.The family of NOX includes seven isoforms,and expressed in different cardiovascular cell types and cell compartments,modulating multiple functions,such as cell proliferation,migration,differentiation,apoptosis,senescence,and inflammatory responses.The NOX-derived ROS are involved in many processes associated with cardiovascular diseases,such as hypertension,atherosclerosis,diabetic vascular disease,ventricular remodeling after myocardial infarction,and so on.
作者
曹静
刘昭娅
胥茜
石瑞正
张国刚
CAO Jing;LIU Zhaoya;XU Qian;SHI Ruizheng;ZHANG Guogang(Department of Cardiovascular Medicine,Xiangya Hospital,Central South University,Changsha 410008,China)
出处
《中南大学学报（医学版）》
CAS
CSCD
北大核心
2019年第11期1258-1267,共10页
Journal of Central South University ：Medical Science
基金
国家重点基础研究发展计划(2014CB542402)
中南大学中央高校基本科研业务费专项资金资助(2018zzts896)~~
关键词
活性氧
烟酰胺腺嘌呤二核苷酸磷酸氧化酶
结构
心血管疾病
reactive oxygen species
nicotinamide adenine dinucleotide phosphate oxidase
structure
cardiovascular diseases
