摘要
Dear Editor,Safeguard!ng cellular redox homeostasis is crucial for maintaining organism health and preventing diseases.Oxidative stress,often characterized by decreased mitochondrial integrity and increased reactive oxygen species(ROS)product!on,disrupts proteostasis and genomic stability,which may eventually lead to cellular decomposition(Oh et al.,2014).Stem cells(such as mesenchymal stem cells,MSCs,and neural stem cells,NSCs)are susceptible to various external and internal stresses,and their dysfunction con tributes to aging and agin g-related diseases.Thus,it is of importance to elucidate the complex signaling networks regulated by oxidative stress in stem cells.Although redox signaling has been implicated in multiple cellular processes,how the redox system functions in various human stem cells is unclear.
基金
This work was supported by the National Key Research and Development Program of China(2017YFA0102802)
the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16010100)
Major Program of Development Fund for Shanghai Zhangjiang National In novati on Demonstrati on Zone(ZJ2018-ZD-004)
the National Key Research and Development Program of China(2018YFC2000100,2015CB964800,2017 YFA0103304,2018YFA0107203,2017YFA0504000,2019YFA0110100)
the National Natural Science Foundation of China(Grant Nos.81625009,91749202,91749123,31671429,81671377,81771515,31601158,81701388,81601233,31601109,81822018,8187022&81801399,31801010,81801370,81861168034,81921006,81922027,31900523,81901432,31900524,81901433)
Beijing Natural Science Foundation(Z190019)
Beijing Municipal Commission of Health and Family Planning(PXM2018_026283_000002)
Advan ced Inn ovation Center for Human Brain Protectio n(3500-1192012)
the State Key Laboratory of Membrane Biology and Youth Innovation Promotion Association,CAS(to LW).
