摘要
线粒体是真核生物母系遗传的多功能细胞器,不仅参与细胞能量代谢的调节,而且参与应激细胞的存活和命运决定。线粒体转移是间充质干细胞参与组织损伤修复和伤口愈合的重要机制之一。线粒体转移的途径有很多种,主要包括隧道纳米管、间隙连接通道、微泡、细胞融合以及胞吞作用等。多条信号传导通路可诱导隧道纳米管的形成,使线粒体从一个细胞转移到另一个细胞。多种应激信号,例如受损线粒体、线粒体DNA或线粒体其它产物的释放以及活性氧水平的升高等,都能引发线粒体从间充质干细胞转移到受体细胞。该文介绍线粒体从间充质干细胞转移到邻近应激细胞的现象,并讨论线粒体转移的可能机制及其在组织损伤等疾病治疗中的作用。
Mitochondria are maternally inherited multifunctional organelles,which not only regulate the energy metabolism,but also the survival and fate of stressed cells.Mitochondrial transfer is one of the emerging mechanisms through which mesenchymal stem cells(MSCs)can repair injured tissues and facilitate wound healing.Several modes of mitochondrial transfer were discovered,such as formation of tunneling nanotubes,gap junction,microvesicles,cell fusion,and endocytosis.Multiple signaling pathways can promote the formation of tunneling nanotubes for mitochondria trafficking from one cell to another.Different stress signals,such as release of injured mitochondria,mtDNA,and mitochondrial products,or the elevated reactive oxygen species promote the transfer of mitochondria from MSCs to the recipient cells.In this review,we provide an overview of the current literature on mitochondrial transfer from MSCs to neighboring stressed cells,and further discuss the possible mechanisms mediating their intercellular transmission and the therapeutic application in treatment of tissue injury.
作者
黄庆雷
沈丽
邓钺
HUANG Qinglei;SHEN Li;DENG Yue(Beijing Cellonis Biotechnologies Co.,Ltd,Beijing 100191,China;Department of Cell Biology,Peking University Health Science Center,Beijing 100191,China)
出处
《中国细胞生物学学报》
CAS
CSCD
2019年第9期1822-1831,共10页
Chinese Journal of Cell Biology
关键词
线粒体转移
隧道纳米管
间隙连接通道
mitochondrial transfer
tunneling nanotubes
gap junction channels
