摘要
干细胞将具有正常功能的线粒体转移至损伤肺细胞并重建其功能，是干细胞治疗肺损伤的重要机制之一。线粒体转移需要通过细胞问形成的间隙链接通道（GJCs）实现，且具有单向性。本文通过对干细胞治疗肺损伤的线粒体转移机制的相关研究进行综述，了解线粒体在肺内生理和病理作用及线粒体转移机制对各类肺损伤的干细胞治疗的临床意义。
Stem cells transfer normal functional mitochondria to injured lung cells and reconstruct their function, which is one of the important mechanisms of stem cells in the treatment of lung injury. Mitochondrial translocation is mediated by intercellular gap junction （GJCs）, which is unidirectional. This paper reviewed the research of stem cells for the treatment of lung injury mitochondrial transfer mechanism, to understand the clinical significance of lung mitochondria in physiological and pathological roles of mitochondria and transfer mechanisms of stem cells for the treatment of various types of lung injury.
出处
《中华危重病急救医学》
CAS
CSCD
北大核心
2018年第1期88-90,共3页
Chinese Critical Care Medicine
基金
国家自然科学基金（81360292）
全军后勤科研计划重大专项课题（AWS14C001）
关键词
干细胞
线粒体转移
肺损伤
间隙链接通道
机制
Stem cell
Mitochondrial transfer
Lung injury
Gap junction channel
Mechanism
