摘要
急性肺损伤（acute lung injury,ALI）以及它的严重形式——急性呼吸窘迫综合征（acute respiratorydistress syndrome,ARDS）是危重病人发病和死亡的重要原因之一,最近2个世纪以来,死亡率仍在36%～44%左右。ALI/ARDS的病因众多,发病机制十分复杂,涉及的环节多,受损的靶细胞多,主要涉及的环节有：炎症反应失控、细胞损伤与修复。
Acute lung injury（ALI） and acute respiratory distress syndrome（ARDS） represent the leading cause of morbidity and mortality in critical patients.Despite improvements in supportive care and mechanical ventilation,recent data indicate that the mortality of ALI/ARDS is still high.Cell-based therapy with stem cells is an attractive new therapeutic approach.Stem cells have the capacity to secrete multiple paracrine factors that can regulate inflammation,improve alveolar fluid clearance,regulate endothelial and epithelial permeability,enhance tissue repair via chemotaxis and inhibit bacterial growth.This review focuses on the recent studies,which support the potential therapeutic use of stem cells in ALI/ARDS with an emphasis on the role of paracrine soluble factors.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2012年第4期755-759,共5页
Chinese Journal of Pathophysiology
基金
国家自然科学基金资助项目(No.81060155)
江西省科技厅支撑计划(No.2010BSA10300)
关键词
干细胞
急性肺损伤
呼吸窘迫综合征
急性
Stem cells
Acute lung injury
Respiratory distress syndrome
acute
