摘要
隧道纳米管(tunneling nanotubes,TNTs)是主要以肌动蛋白为骨架形成的细胞间管道结构,相当于连接细胞之间的桥梁。作为新发现的细胞间通信机制,TNTs能够实现细胞间长距离的通信与物质的定向运输,介导细胞器、核酸、小分子蛋白等物质在细胞间转移。TNTs借助自身的通讯与运输功能影响神经退行性疾病、癌症等疾病的发生发展,同时也为相关疾病的治疗提供一些新思路、新靶点。本篇综述详细介绍了TNTs的形态结构、形成机制、形成相关调节因子、功能特性以及生理学意义。
Tunneling nanotubes(TNTs)are intercellular pipe structures formed mainly by actin,which are equivalent to bridges connecting cells.As a newly discovered mechanism of intercellular communication,TNTs realize long⁃distance communication and directional transport of substances between cells.TNTs mediate the transfer of organelles,nucleic acids,small molecular proteins and other substances between cells.TNTs use communication and transportation functions to influence the occurrence and development of neurodegenerative diseases,tumors,cancers and other diseases,and provide some new ideas and new targets for the treatment of related diseases.This review introduces the morphological structure,formation mechanism,formation related regu⁃latory factors,functions and physiological significance of TNTs.
作者
曹静
邓洋
高磊
罗昕悦
李峰
CAO Jing;DENG Yang;GAO Lei;LUO Xinyue;LI Feng(School of Public Health,Baotou Medical College,Baotou 014000,China;不详)
出处
《实用医学杂志》
CAS
北大核心
2023年第13期1719-1723,共5页
The Journal of Practical Medicine
基金
国家自然科学基金项目(编号:82260650,82160624)。
关键词
隧道纳米管
细胞通讯
疾病
tunneling nanotubes
intercellular communication
disease
