摘要
脑卒中常导致持续性脑卒中后认知障碍(PSCI),主要表现为学习、记忆等方面的障碍。目前,PSCI发病机制尚不完全清楚,但与线粒体功能障碍密切相关,健康线粒体对神经元存活至关重要。近年来研究表明,细胞间线粒体转移可通过增加神经元活力、增强线粒体代谢、调控神经炎症等过程与脑卒中联系,从而改善认知障碍。本文概述了线粒体转移的机制以及细胞间线粒体转移在PSCI中的关键作用,并探讨了线粒体移植作为PSCI的新型治疗干预措施的效果,为其临床防治提供参考。
Stroke often leads to persistent post-stroke cognitive impairment(PSCI),which mainly manifests as impairment in learning and memory.The pathogenesis remains unclear as present,but it is closely related to mitochondrial dysfunction,and healthy mitochondria are essential for neuronal survival.Recent studies have shown that intercellular mitochondrial transfer can be linked to stroke through increasing neuronal viability,enhancing mitochondrial metabolism,and modulating neuroinflammation,thereby improving cognitive impairment.This review overviews the mechanisms of mitochondrial transfer and the key role of intercellular mitochondrial transfer in PSCI,and discusses that mitochondrial transplantation may serve as a novel therapeutic intervention for PSCI,providing references for its clinical management.
作者
肖雨倩
白艳杰
王岩
陈淑颖
陈丽敏
孙可心
万俊
XIAO Yuqian;BAI Yanjie;WANG Yan;CHEN Shuying;CHEN Limin;SUN Kexin;WAN Jun(Henan University of Chinese Medicine,Zhengzhou 450046,China;The First Affiliated Hospital of Henan University of CM,Zhengzhou 450000,China)
出处
《中国全科医学》
北大核心
2023年第30期3833-3840,共8页
Chinese General Practice
基金
国家重点研发计划(2018YFC1706004)
河南省中医药科学研究专项重点课题(20-21ZY1009)
河南省中医药传承与创新人才工程(仲景工程)中医药学科拔尖人才(CZ0237-08)
河南省科技攻关计划(222102310529)
河南省卫健委国家中医临床研究基地科研专项(2022JDZX005)
河南省中医药拔尖人才培养项目专项课题(2022ZYBJ07)。
关键词
卒中
认知障碍
线粒体转移
隧道纳米管
细胞外囊泡
间隙连接
综述
Stroke
Cognition disorders
Mitochondrial transfer
Tunneling nanotubes
Extracellular vesicles
Gap junction
Review
