摘要
目的分析慢性乙型肝炎(CHB)患者病情严重程度与血清钙(Ca)水平的相关性。方法纳入2017年7月-2018年7月我院66例CHB患者为CHB组,根据其病情严重程度分为轻度组(n=25)、中度组(n=22)、重度组(n=19)3个亚组;将同期30例健康体检者纳入对照组(n=30)。比较各组受试者血清Ca、骨钙素(BGP)、1,25-二羟维生素D3[1,25(OH)2D3]及凝血四项[凝血酶时间(TT)、活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、纤维蛋白原(FIB)]水平差异,分析血清Ca水平与CHB病情严重程度的相关性。结果血清Ca、BGP、1,25(OH)2D3、FIB水平重度组低于轻、中度组和对照组,中度组低于轻度组和对照组,轻度组低于对照组(P<0.05);TT、APTT、PT水平重度组高于轻、中度组和对照组,中度组高于轻度组和对照组,轻度组高于对照组(P<0.05)。血清Ca水平与CHB病情严重程度及TT、PT、APTT水平呈显著负相关性(P<0.05),与FIB水平呈正相关性(P<0.05)。结论CHB患者存在不同程度的骨代谢紊乱,血清Ca水平降低与CHB病情进展密切相关,检测该指标对评估患者病情、指导临床治疗有一定价值。
Objective To analyze the correlation between disease severity and serum calcium(Ca)level in patients with chronic hepatitis B(CHB).Methods 66CHB patients in our hospital from July 2017to July 2018were included in CHB group.According to the disease severity,they were divided into three subgroups of mild group(n=25),moderate group(n=22)and severe group(n=19).Another 30healthy examiners at the same time period were included in control group(n=30).The serum Ca,bone gla protein(BGP),1,25-dihydroxyvitamin D3[1,25(OH)2D3]and coagulation four indices[thrombin time(TT),activated partial thromboplastin time(APTT),prothrombin time(PT),fibrinogen(FIB)]were among among all groups,and the correlation between serum Ca level and CHB severity was analyzed.Results Serum levels of Ca,BGP,1,25(OH)2D3and FIB in severe group were lower than those in mild group and moderate group,and the levels in moderate group were lower than those in mild group and control group,and the levels in mild group were lower than those in control group(P<0.05).The levels of TT,APTT and PT in severe group were higher than those in mild group,moderate group and control group,and the levels in moderate group were higher than those in mild group and control group,and the levels in mild group were higher than those in control group(P<0.05).Serum Ca level was significantly negatively correlated with CHB severity and levels of TT,PT and APTT(P<0.05),and was positively correlated with FIB level(P<0.05).Conclusion There are different degrees of bone metabolism disorder in patients with CHB.The decrease of serum Ca level is closely related to the progression of CHB.The detection of this index has certain value for evaluating patients’condition and guiding clinical treatment.
作者
徐晓义
夏树伟
黄小俊
潘艳
XU Xiao-yi;XIA Shu-wei;HUANG Xiao-jun;PAN Yan(Department of Infectious medicine,Tianmen First People’s Hospital,Tianmen Maternal and Child Health Hospital,Tianmen 431700,China;Departmentof Pediatrics,Tianmen Maternal and Child Health Hospital,Tianmen 431700,China)
出处
《中国实验诊断学》
2019年第11期1929-1931,共3页
Chinese Journal of Laboratory Diagnosis
关键词
慢性乙型肝炎
血清钙
凝血四项
骨代谢
Chronic hepatitis B
Blood calcium
Coagulation four indices
Bone metabolism
