摘要
目的探讨血清25-羟维生素D_(3)[25(OH)D_(3)]与乙型肝炎活动度和抗病毒疗效的关系。方法回顾性分析2020年5月—2022年3月在本院接受治疗的142例慢性乙型肝炎患者的临床资料,应用Scheuer评分系统对肝脏炎症活动度进行分期,将142例患者分为G1期组16例、G2期组49例、G3期组54例、G4期组23例;另外选择健康体检者作为对照组,比较所有研究对象的实验室指标水平,分析实验室指标与肝脏炎症分期的相关性;根据6个月后抗病毒疗效将CHB患者分为有效组99例和无效组43例,比较2组患者实验室指标,采用logistic回归分析抗病毒疗效的影响因素,应用受试者工作特征曲线(ROC)分析实验室指标预测抗病毒疗效的价值。结果CHB组患者抗CRP、ALT、AST、GGT、TBiL水平高于对照组,25(OH)D_(3)水平低于对照组(P<0.05);CHB患者CRP、ALT、AST、GGT、TBiL水平与肝脏炎症分期成正相关关系,25(OH)D_(3)水平与肝脏炎症分期成负相关关系(P<0.05);有效组患者CRP水平低于无效组,HBcAb、25(OH)D_(3)水平高于无效组(P<0.05);HBcAb、CRP、25(OH)D_(3)是CHB抗病毒疗效的影响因素(P<0.05);ROC分析结果显示,HBcAb、CRP、25(OH)D_(3)预测HBVDNA转阴的AUC分别为0.691、0.695、0.786。结论25(OH)D_(3)水平与CHB肝脏炎症活动度和抗病毒疗效显著相关,可为肝脏炎症分期评估和抗病毒疗效预测提供参考。
Objective This paper aims to investigate the relationship of serum 25-hydroxyvitamin D_(3)[25(OH)D_(3)]with activity and antiviral efficacy in patients with hepatitis B.Methods The clinical data of 142 patients with chronic hepatitis B treated in our hospital from May 2020 to March 2022 were retrospectively analyzed.Patients were divided into G1 stage group(16 cases),G2 stage group(49 cases),G3 stage group(54 cases)and G4 stage group(23 cases)according to the Scheuer score.In addition,healthy subjects were selected as the control group.The serological indexes of all subjects were compared,and the correlation between serological indexes and liver inflammation stage was analyzed.According to the antiviral efficacy after 6 months,CHB patients were divided into effective group(n=99)and ineffective group(n=43).The serological indexes of the two groups were compared,and the value of serological indexes in predicting the antiviral efficacy was analyzed by receiver operating characteristic curve(ROC).Results The levels of CRP ALT,AST,GGT and TBiL in CHB group were higher than those in control group,the level of 25(OH)D_(3) was lower in CHB group than that in control group(P<0.05).The levels of CRP,ALT,AST,GGT,TBiL in CHB patients were positively correlated with liver inflammation stage,HBcAb and 25(OH)D_(3) were negatively correlated with liver inflammation stage(P<0.05).The level of CRP in effective group was lower than that in ineffective group,and HBcAb and 25(OH)D_(3) levels in effective group were higher than those in the ineffective group(P<0.05).HBcAb,CRP and 25(OH)D_(3) were influencing factors of antiviral efficacy of CHB(P<0.05).ROC analysis showed that the AUC of HBcAb,CRP and 25(OH)D_(3) in predicting the antiviral efficacy were 0.691,0.695 and 0.786,respectively.Conclusion 25(OH)D_(3) level is correlated with liver inflammation activity and antiviral efficacy in CHB,which can provide reference for staging evaluation of liver inflammation and prediction of antiviral efficacy.
作者
王慧芬
杨利萍
WANG Hui-fen;YANG Li-ping(Clinical Laboratory,Quzhou People's Hospital Affiliated to Wenzhou Medical University(Quzhou People's Hospital),Zhejiang 324000,China)
出处
《中国卫生检验杂志》
CAS
2023年第14期1741-1744,1753,共5页
Chinese Journal of Health Laboratory Technology
