摘要
目的 探究预防性静滴钾离子、镁离子对急性心梗后并发室性心律失常的预防作用.方法 选择2015年1月-2018年1月于西宁市第一人民医院进行治疗的78例急性心肌梗死患者为研究对象,按照随机数字表法将其均分为观察组与对照组,每组各39例患者.对照组患者进行常规急性心梗治疗,观察组患者在对照组基础上加用门冬氨酸钾镁进行治疗,对比两组治疗有效率,对比两组治疗前后血液流变学指标纤维蛋白原(Fib)、凝血酶原时间(PT)、血小板计数(Plt),对比两组治疗期间不良反应发生率及心律失常发生率.结果 治疗后,观察组患者治疗有效率为87.18%,对照组为76.92%,两组对比差异具有统计学意义(P<0.05).治疗前两组患者Fib、PT以及Plt水平对比差异不具有统计学意义;治疗后,两组患者Plt及Fib水平低于治疗前,PT水平高于治疗前,差异有统计学意义(P<0.05);治疗后观察组患者Plt及Fib水平低于对照组,PT水平高于对照组(P<0.05).观察组患者不良反应发生率稍高于对照组,但对比差异不具有统计学意义.观察组心律失常发生率为7.69%,对照组为15.38%,两组对比差异具有统计学意义(P<0.05).结论 预防性静滴钾离子与镁离子能够显著降低急性心梗患者心律失常发生率,同时有利于提高治疗有效率,改善其血流变指标,且安全性较高.
Objective To explore the preventive effect of intravenous potassium ion and magnesium ion on ventricular arrhythmia after acute myocardial infarction.Methods 78 patients with acute myocardial infarction who were treated in Xining No.1 People's Hospital from January 2015 to January 2018 were divided into observation group and control group according to random number table method,each group had 39 patients.Patients in the control group were treated with routine acute myocardial infarction treatment.The observation group was treated with potassium aspartate and magnesium aspartate on the basis of the control group.And the effective rate was compared between two groups.The hemorheological indexes,such as Fib,PT,and Pit were compared before and after treatment in two groups.The incidence of adverse reactions and arrhythmias during treatment were compared between two groups.Results After treatment,the effective rate was 87.18%in the observation group and 76.92%in the control group,the difference between the two groups was statistically significant(P<0.05).Before treatment,there was no significant difference in the levels of Fib,PT and Pit between two groups.After treatment,the levels of Pit and Fib in the observation group were decreased,and PT levels were higher than before treatment,with statistically significant differences in the same group(P<0.05).After treatment,Pit and Fib levels in the observation group were lower than those in the control group,and PT levels were higher than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was slightly higher than that in the control group,but the difference was not statistically significant.The incidence of arrhythmia in the observation group was 7.69%,and that in the control group was 15.38%(P<0.05).Conclusion Preventive intravenous drip of potassium ion and magnesium ion can significantly reduce the incidence of arrhythmia in patients with acute myocardial infarction,at the same time,it is conducive to improve the treatment effi
作者
王武
WANG Wu(Department of Cardiovascular Medicine,Xining No.l People's Hospital,Xining 810000,China)
出处
《药物评价研究》
CAS
2019年第11期2218-2221,共4页
Drug Evaluation Research
关键词
钾离子
镁离子
急性心梗
心律失常
potassium ion
magnesium ion
acute myocardial infarction
arrhythmia
