摘要
目的探讨血清钙(Ca)、铝(Al)、砷(As)、钴(Co)、镁(Mg)、磷(P)、铁(Fe)、甲状旁腺激素(PTH)及降钙素(Ct)水平与原发性家族性脑钙化(PFBC)疾病及其临床症状的相关性。方法2015年7月至2016年10月,收集17个PFBC家系的临床资料,PFBC患者根据临床症状进行分组,比较病例组和健康组、有症状组和无症状组、有症状组间运动受损组和精神症状组、运动受损和精神症状家系中的有症状组和无症状组间的血清Ca、Al、As、Co、Mg、P、Fe、PTH、Ct水平的差异。结果病例组和健康组、有症状组和无症状组、有症状组间运动受损组和精神症状组、运动受损和精神症状家系中的有症状组和无症状组患者血清中Ca、Al、As、Co、Mg、P、Fe、PTH、Ct水平比较差异均无统计学意义(P>0.05)。结论17个PFBC家系中,血清Ca、Al、As、Co、Mg、P、Fe、PTH和Ct水平与PFBC疾病无关,与临床症状无关。
Objective To investigate the correlation between Ca,Al,As,Co,Mg,P,Fe,parathyroid hormone( PTH),Ct levels and primary familial brain calcification( PFBC). Methods We recruited 17 PFBC families from July,2015 to October,2016. Groups were divided according to clinical symptoms,the serum concentrations of Ca,P,Fe,Al,As,Co,PTH and Ct were compared among different family groups. Results There was no significant difference in serum levels of Ca,P,Fe,Al,As,Co,PTH and Ct among the healthy and patient groups or the symptomatic and asymptomatic groups,symptomatic and asymptomatic groups in movement disorder families and in psychiatric families( P > 0. 05). Conclusions Among the 17 PFBC families,neither serum concentrations of Ca,Al,As,Co,Mg,P,and Fe nor the levels of PTH and Ct were associated with PFBC.
作者
黄远桃
李梅芳
张伟
邹国英
吴石星
李萍
李小娟
Huang Yuantao;Li Meifang;Zhang Wei;Zou Guoying;Wu Shixing;Li Ping;Li Xiaojuan(Department of Neurology,the Brain Hospital of Hunan Province,Changsha 410007,China;Otolaryngology Head and Neck、the Brain Hospital of Hunan Province,Changsha 410007,China;Department of Radiology,the Brain Hospital of Hunan Province,Changsha 410007、China;Clinical laboratory,the Brain Hospital of Hunan Province,Changsha 410007,China)
出处
《中国医师杂志》
CAS
2019年第11期1636-1639,共4页
Journal of Chinese Physician
基金
湖南省卫生计生委资助项目(B2015-106)
湖南省科技厅资助项目(S2018JJ6012,2018SK50603)~~
关键词
基底神经节疾病
钙质沉着症
神经变性疾病
钙
痕量元素
Basal ganglia diseases
Calcinosis
Neurodegenerative diseases
Calcium
Trace elements
