摘要
白血病是一类造血干细胞恶性克隆性疾病,其根本原因是造血干细胞/祖细胞内部遗传物质的结构和功能的改变。DNA不再是影响遗传的唯一物质,针对DNA以外遗传物质的研究越来越深入,科学家发现表观遗传学异常也是白血病发病机制的重要组成部分。表观遗传学涉及DNA、蛋白质、染色质和RNA等多个水平,而不同水平在调控基因表达上相互关联、彼此牵制。近年来,染色质重塑已成为肿瘤学表观遗传领域的研究热点,其在基因表达调控中的作用已得到大家公认。本文介绍染色质重塑及复合物分类,与人类疾病特别是白血病的关系,同时讨论染色质重塑研究中存在的不足和应用前景,为白血病的治疗寻求新的方向。
Leukemia is a type of malignant clonal disease of hematopoietic stem cells.Its root cause is the change in the structure and function of genetic material inside hematopoietic stem/progenitor cells.DNA is no longer the only substance that affects heredity.Research on genetic material other than DNA is getting deeper.Scientists have found that epigenetic abnormality is also an important part of the pathogenesis of leukemia.Epigenetics involves DNA,protein,chromatin and RNA,and they are interrelated and regulated by each other in regulating gene expression.In recent years,chromatin remodeling has become a research focus in the field of oncology epigenetics,and its role in regulation of gene expression has been commonly recognized.To explore the potential value of chromatin remodeling in human pathogenesis and therapeutics,this review describes chromatin remodeling and remodeling factor classification,as well as its impact on human diseases,particularly leukemia.
作者
李亮亮
李冬娜
杜乐
任立成
LI Liang-liang;LI Dong-na;DU Le;REN Li-cheng(Department of Biology,Hainan Medical University,Haikou 571199,Hainan,China)
出处
《海南医学院学报》
CAS
2019年第22期1752-1755,共4页
Journal of Hainan Medical University
基金
国家自然科学基金(31660318)
海南省研究生创新课题(Hys2018-276)
海南省研究生创新课题(Hys2019-289)~~
